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. 1994 Oct;68(10):6815–6819. doi: 10.1128/jvi.68.10.6815-6819.1994

Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

S Kyuwa 1, M Cohen 1, G Nelson 1, S M Tahara 1, S A Stohlman 1
PMCID: PMC237110  PMID: 8084020

Abstract

Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1 beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.

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Selected References

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