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. 1993 Mar;67(3):1328–1333. doi: 10.1128/jvi.67.3.1328-1333.1993

Immediate-early transcription over covalently joined genome ends of bovine herpesvirus 1: the circ gene.

C Fraefel 1, U V Wirth 1, B Vogt 1, M Schwyzer 1
PMCID: PMC237501  PMID: 8382298

Abstract

Herpesvirus genomes are linear molecules in virions. Prior to replication in host cells, they form circular templates by unknown mechanisms. Examining lytic infection with bovine herpesvirus 1, we observed immediate-early transcription over joined genome ends, which suggested that circles are present at the initial stage of infection. Among the transcripts was a spliced immediate-early RNA (1.5 kb) sharing exon 1 with previously described major immediate-early transcripts from the right genome end and exon 2 with a late transcript located near the left genome end. Exon 2 encodes a putative circ-encoded protein with homology to the varicella-zoster virus open reading frame 2 and equine herpesvirus 1 open reading frame 3 products. The novel features reported here for bovine herpesvirus 1 may constitute a more general property of herpesviruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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