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. 1993 Feb;69(808):95–99. doi: 10.1136/pgmj.69.808.95

IgA nephropathy in hereditary angioedema.

J Srinivasan 1, P Beck 1
PMCID: PMC2399629  PMID: 8506211

Abstract

Hereditary angioedema is an autosomal dominant disorder of the complement system in which there is a deficiency of the inhibitor of the activated first component of complement. We have previously reported on three generations of a family with classic hereditary angioedema. Three members of this family have now developed IgA nephropathy. The association of hereditary angioedema with various immunoregulatory disorders has been previously reported but this is the first report of IgA nephropathy in association with this condition.

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Selected References

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  1. Beck P., Willis D., Davies G. T., Lachmann P. J., Sussman M. A family study of hereditary angioneurotic oedema. Q J Med. 1973 Apr;42(166):317–339. [PubMed] [Google Scholar]
  2. Berger J., Hinglais N. Les ddpôts intercapillaires d'IgA-IgG. J Urol Nephrol (Paris) 1968 Sep;74(9):694–695. [PubMed] [Google Scholar]
  3. Berthoux F. C., Genin C., Le Petit J. C., Laurent B. Immunogénétique des glomérulonéphrites intercapillaires à dépôts d'IgA. Nephrologie. 1983;4(6):283–287. [PubMed] [Google Scholar]
  4. Bond W. R., Jr, Herrod H. G., Duberstein L. E. Hereditary angioedema: association with IgA deficiency and otolaryngologic disorders. Laryngoscope. 1981 Mar;91(3):416–421. doi: 10.1288/00005537-198103000-00012. [DOI] [PubMed] [Google Scholar]
  5. Brickman C. M., Tsokos G. C., Balow J. E., Lawley T. J., Santaella M., Hammer C. H., Frank M. M. Immunoregulatory disorders associated with hereditary angioedema. I. Clinical manifestations of autoimmune disease. J Allergy Clin Immunol. 1986 May;77(5):749–757. doi: 10.1016/0091-6749(86)90424-0. [DOI] [PubMed] [Google Scholar]
  6. D'Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med. 1987 Sep;64(245):709–727. [PubMed] [Google Scholar]
  7. DONALDSON V. H., EVANS R. R. A BIOCHEMICAL ABNORMALITY IN HEREDIATRY ANGIONEUROTIC EDEMA: ABSENCE OF SERUM INHIBITOR OF C' 1-ESTERASE. Am J Med. 1963 Jul;35:37–44. doi: 10.1016/0002-9343(63)90162-1. [DOI] [PubMed] [Google Scholar]
  8. Donaldson V. H., Ratnoff O. D., Dias Da Silva W., Rosen F. S. Permeability-increasing activity in hereditary angioneurotic edema plasma. II. Mechanism of formation and partial characterization. J Clin Invest. 1969 Apr;48(4):642–653. doi: 10.1172/JCI106022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fields T., Ghebrehiwet B., Kaplan A. P. Kinin formation in hereditary angioedema plasma: evidence against kinin derivation from C2 and in support of "spontaneous" formation of bradykinin. J Allergy Clin Immunol. 1983 Jul;72(1):54–60. doi: 10.1016/0091-6749(83)90052-0. [DOI] [PubMed] [Google Scholar]
  10. Gelfand J. A., Sherins R. J., Alling D. W., Frank M. M. Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976 Dec 23;295(26):1444–1448. doi: 10.1056/NEJM197612232952602. [DOI] [PubMed] [Google Scholar]
  11. Harrington T. M., Torretti D., Pytko V. F., Plotkin G. R. Hereditary angioedema and coronary arteritis. Am J Med Sci. 1984 Jan-Feb;287(1):50–52. doi: 10.1097/00000441-198401000-00014. [DOI] [PubMed] [Google Scholar]
  12. Hiki Y., Kobayashi Y., Tateno S., Sada M., Kashiwagi N. Strong association of HLA-DR4 with benign IgA nephropathy. Nephron. 1982;32(3):222–226. doi: 10.1159/000182849. [DOI] [PubMed] [Google Scholar]
  13. Hosea S. W., Santaella M. L., Brown E. J., Berger M., Katusha K., Frank M. M. Long-term therapy of hereditary angioedema with danazol. Ann Intern Med. 1980 Dec;93(6):809–812. doi: 10.7326/0003-4819-93-6-809. [DOI] [PubMed] [Google Scholar]
  14. Julian B. A., Quiggins P. A., Thompson J. S., Woodford S. Y., Gleason K., Wyatt R. J. Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med. 1985 Jan 24;312(4):202–208. doi: 10.1056/NEJM198501243120403. [DOI] [PubMed] [Google Scholar]
  15. Kijlstra A., van Es L. A., Daha M. R. Effects of C-1 on the size of soluble immune aggregates and on their processing by macrophages. J Immunol. 1979 Aug;123(2):640–645. [PubMed] [Google Scholar]
  16. Oltvai Z. N., Wong E. C., Atkinson J. P., Tung K. S. C1 inhibitor deficiency: molecular and immunologic basis of hereditary and acquired angioedema. Lab Invest. 1991 Oct;65(4):381–388. [PubMed] [Google Scholar]
  17. Plaza J., Malasit P., Kerr D. N. Hereditary angio-oedema with mesangiocapillary glomerulonephritis. Postgrad Med J. 1977 Oct;53(624):627–630. doi: 10.1136/pgmj.53.624.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ROSEN F. S., PENSKY J., DONALDSON V., CHARACHE P. HEREDITARY ANGIONEUROTIC EDEMA: TWO GENETIC VARIANTS. Science. 1965 May 14;148(3672):957–958. doi: 10.1126/science.148.3672.957. [DOI] [PubMed] [Google Scholar]
  19. Tomino Y., Sakai H., Miura M., Suga T., Endoh M., Nomoto Y. Effect of danazol on solubilization of immune deposits in patients with IgA nephropathy. Am J Kidney Dis. 1984 Sep;4(2):135–140. doi: 10.1016/s0272-6386(84)80061-x. [DOI] [PubMed] [Google Scholar]
  20. Wyatt R. J., Julian B. A. Activation of complement in IgA nephropathy. Am J Kidney Dis. 1988 Nov;12(5):437–442. doi: 10.1016/s0272-6386(88)80042-8. [DOI] [PubMed] [Google Scholar]
  21. Wyatt R. J., Julian B. A., Bhathena D. B., Mitchell B. L., Holland N. H., Malluche H. H. Iga nephropathy: presentation, clinical course, and prognosis in children and adults. Am J Kidney Dis. 1984 Sep;4(2):192–200. doi: 10.1016/s0272-6386(84)80071-2. [DOI] [PubMed] [Google Scholar]

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