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. 1992 Nov;66(11):6819–6823. doi: 10.1128/jvi.66.11.6819-6823.1992

Recognition efficiency of the hepatitis B virus polyadenylation signals is tissue specific in transgenic mice.

S Perfumo 1, L Amicone 1, S Colloca 1, M Giorgio 1, L Pozzi 1, M Tripodi 1
PMCID: PMC240185  PMID: 1357192

Abstract

The hepatitis B virus genome contains a unique polyadenylation (TATAAA) signal which is differentially utilized in the formation of the various hepatitis B virus transcripts. A head-to-tail multiple-copy insertion of a viral fragment comprising the viral enhancer, the X promoter, the X open reading frame, and the viral poly(A) signal in transgenic mice allowed us to monitor tissue-specific differences in the expression of transcripts initiating from the X promoter. These transcripts are efficiently processed at the first polyadenylation site in the liver, while in the kidney, the brain, and the testis, a portion of the transcripts covers two copies of the transgene, since only the second polyadenylation site is properly recognized. As discussed in this article, this observation suggests a tissue-specific distribution of cellular factors involved in polyadenylation.

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Selected References

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