Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1978 Sep;54(635):628–632. doi: 10.1136/pgmj.54.635.628

The treatment of lupus nephritis by methyl prednisolone pulse therapy.

S Dosa, S A Cairns, W Lawler, N P Mallick, I N Slotki
PMCID: PMC2425230  PMID: 724583

Abstract

Four patients with proliferative glomerulonephritis due to systemic lupus erythematosus were treated with intravenous methyl prednisolone 'pulse' therapy. In all, eight courses of therapy were given, three for acute oliguric renal failure; and on each occasion there was a good response to the treatment. Clinical, histological and immunological details of the patients are presented. The diagnosis, treatment, and monitoring of disease activity in lupus nephritis are discussed in the light of this experience.

Full text

PDF
630

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman G. L. Alternate-day steroid therapy in lupus nephritis. Ann Intern Med. 1970 Apr;72(4):511–519. doi: 10.7326/0003-4819-72-4-511. [DOI] [PubMed] [Google Scholar]
  2. Baldwin D. S., Lowenstein J., Rothfield N. F., Gallo G., McCluskey R. T. The clinical course of the proliferative and membranous forms of lupus nephritis. Ann Intern Med. 1970 Dec;73(6):929–942. doi: 10.7326/0003-4819-73-6-929. [DOI] [PubMed] [Google Scholar]
  3. Bardana E. J., Jr, Harbeck R. J., Hoffman A. A., Pirofsky B., Carr R. I. The prognostic and therapeutic implications of DNA:anti-DNA immune complexes in systemic lupus erythematosus (SLE). Am J Med. 1975 Oct;59(4):515–522. doi: 10.1016/0002-9343(75)90259-4. [DOI] [PubMed] [Google Scholar]
  4. Bulkley B. H., Roberts W. C. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients. Am J Med. 1975 Feb;58(2):243–264. doi: 10.1016/0002-9343(75)90575-6. [DOI] [PubMed] [Google Scholar]
  5. Cameron J. S., Lessof M. H., Ogg C. S., Williams B. D., Williams D. G. Disease activity in the nephritis of systemic lupus erythematosus in relation to serum complement concentrations. DNA-binding capacity and precipitating anti-DNA antibody. Clin Exp Immunol. 1976 Sep;25(3):418–427. [PMC free article] [PubMed] [Google Scholar]
  6. Cathcart E. S., Idelson B. A., Scheinberg M. A., Couser W. G. Beneficial effects of methylprednisolone "pulse" therapy in diffuse proliferative lupus nephritis. Lancet. 1976 Jan 24;1(7952):163–166. doi: 10.1016/s0140-6736(76)91272-1. [DOI] [PubMed] [Google Scholar]
  7. Cohen A. S., Canoso J. J. Criteria for the classification of systemic lupus erythematosus--status 1972. Arthritis Rheum. 1972 Sep-Oct;15(5):540–543. doi: 10.1002/art.1780150512. [DOI] [PubMed] [Google Scholar]
  8. DUBOIS E. L., TUFFANELLI D. L. CLINICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS. COMPUTER ANALYSIS OF 520 CASES. JAMA. 1964 Oct 12;190:104–111. doi: 10.1001/jama.1964.03070150014003. [DOI] [PubMed] [Google Scholar]
  9. Epstein W. V. Immunologic events preceding clinical exacerbation of systemic lupus erythematosus. Am J Med. 1973 May;54(5):631–636. doi: 10.1016/0002-9343(73)90121-6. [DOI] [PubMed] [Google Scholar]
  10. Estes D., Christian C. L. The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 1971 Mar;50(2):85–95. doi: 10.1097/00005792-197103000-00001. [DOI] [PubMed] [Google Scholar]
  11. Feng P. H., Cheah P. S., Lee Y. K. Mortality in systemic lupus erythematosus: a 10-year review. Br Med J. 1973 Dec 29;4(5895):772–774. doi: 10.1136/bmj.4.5895.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gary N. E., Maher J. F., Schreiner G. E. Lupus nephritis. Renal function after prolonged survival. N Engl J Med. 1967 Jan 12;276(2):73–78. doi: 10.1056/NEJM196701122760202. [DOI] [PubMed] [Google Scholar]
  13. Jones J. V., Cumming R. H., Bucknall R. C., Asplin C. M. Plasmapheresis in the management of acute systemic lupus erythematosus? Lancet. 1976 Apr 3;1(7962):709–711. doi: 10.1016/s0140-6736(76)93088-9. [DOI] [PubMed] [Google Scholar]
  14. Levinsky R. J., Cameron J. S., Soothill J. F. Serum immune complexes and disease activity in lupus nephritis. Lancet. 1977 Mar 12;1(8011):564–567. doi: 10.1016/s0140-6736(77)91998-5. [DOI] [PubMed] [Google Scholar]
  15. POLLAK V. E., PIRANI C. L., KARK R. M. Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis. J Lab Clin Med. 1961 Apr;57:495–511. [PubMed] [Google Scholar]
  16. Pollak V. E., Pirani C. L., Dujovne I., Dillard M. G. The clinical course of lupus nephritis: relationship to the renal histologic findings. Perspect Nephrol Hypertens. 1973;1(Pt 2)(0):1167–1181. [PubMed] [Google Scholar]
  17. Ponticelli C., Imbasciati E., Brancaccio D., Tarantino A., Rivolta E. Acute renal failure in systemic lupus erythematosus. Br Med J. 1974 Sep 21;3(5933):716–719. doi: 10.1136/bmj.3.5933.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Schur P. H., Sandson J. Immunologic factors and clinical activity in systemic lupus erythematosus. N Engl J Med. 1968 Mar 7;278(10):533–538. doi: 10.1056/NEJM196803072781004. [DOI] [PubMed] [Google Scholar]
  19. Sharp G. C., Irvin W. S., LaRoque R. L., Velez C., Daly V., Kaiser A. D., Holman H. R. Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy. J Clin Invest. 1971 Feb;50(2):350–359. doi: 10.1172/JCI106502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Urowitz M. B., Bookman A. A., Koehler B. E., Gordon D. A., Smythe H. A., Ogryzlo M. A. The bimodal mortality pattern of systemic lupus erythematosus. Am J Med. 1976 Feb;60(2):221–225. doi: 10.1016/0002-9343(76)90431-9. [DOI] [PubMed] [Google Scholar]
  21. Zweiman B., Kornblum J., Cornog J., Hildreth E. A. The prognosis of lupus nephritis. Role of clinical-pathologic correlations. Ann Intern Med. 1968 Sep;69(3):441–462. doi: 10.7326/0003-4819-69-3-441. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES