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. 1971 Feb;105(2):565–572. doi: 10.1128/jb.105.2.565-572.1971

Recovery from N-Hydroxyurethan-Induced Death

Kathleen P Mullinix a,1, Herbert S Rosenkranz a
PMCID: PMC248423  PMID: 5541533

Abstract

Bacteria (Escherichia coli) can recover from the lethal action of N-hydroxyurethan when they are incubated in drug-free liquid medium. This recovery, which is dependent upon energy metabolism, does not occur on solid medium. Recovery is accompanied by repair of the cellular deoxyribonucleic acid (DNA). A bacterial mutant deficient in DNA polymerase was extremely sensitive to the lethal action of hydroxyurethan. Data are presented which support the concept that DNA replication and DNA repair are mediated by different enzymes and that only the former process is inhibited by hydroxyurea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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