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. 1981 Oct;40(1):314–318. doi: 10.1128/jvi.40.1.314-318.1981

Varicella-zoster virus vaccine DNA differs from the parental virus DNA.

J R Ecker, R W Hyman
PMCID: PMC256623  PMID: 6270384

Abstract

The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.

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Selected References

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