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. 1989 Oct;57(10):2977–2983. doi: 10.1128/iai.57.10.2977-2983.1989

Antichlamydial specificity of conjunctival lymphocytes during experimental ocular infection.

J A Whittum-Hudson 1, H R Taylor 1
PMCID: PMC260758  PMID: 2476396

Abstract

Antigen-specific responses to chlamydiae have been demonstrated with lymphocytes isolated from the conjunctiva after primary ocular infection and after topical challenge of chlamydia-immune cynomolgus monkeys with noninfectious, Triton X-100-extracted antigen. Proliferative to viable elementary bodies homologous to the original infecting serovar were demonstrated. In addition, in vitro production of antichlamydial antibody by conjunctival B cells was demonstrated by enzyme-linked immunosorbent assay of culture supernatants collected after 7 to 21 days of culture. These findings demonstrate that antigen-specific lymphocytes appear in the conjunctiva as a result of ocular chlamydial infection and that a noninfectious chlamydial antigen stimulates their reappearance or expansion at the site of original infection.

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Selected References

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