Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1983 Aug;41(2):494–500. doi: 10.1128/iai.41.2.494-500.1983

Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia.

E C Hahn, P S Hahn
PMCID: PMC264668  PMID: 6192083

Abstract

The contributions to Aleutian disease gammopathy of specific antiviral antibody and an autoimmune component, anti-DNA antibody, were studied with pastel ranch mink naturally infected with Aleutian disease virus. Specific antibody activities were determined by countercurrent immunoelectrophoresis and radioimmune assay, respectively. Gamma globulin levels (percent gamma) were determined by serum electrophoresis. Within an infected mink population, it was possible to predict the level of gammopathy from measurement of the two antibody levels. For the mink serum samples used, there was better correlation between anti-DNA antibody levels and total serum immunoglobulin than between anti-Aleutian disease virus antibody titers and percent gamma. With serum samples taken over a 2-week interval, significant increases were measured in anti-DNA antibody and percent gamma. Increases in anti-Aleutian disease virus titers during this period were not significant. The results suggest that the continuing increases in serum immunoglobulin in Aleutian disease virus-infected mink are due to both a specific antiviral response and an autoimmune response, as reflected in generation of anti-DNA antibody.

Full text

PDF
499

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aasted B. Purification and characterization of Aleutian disease virus. Acta Pathol Microbiol Scand B. 1980 Dec;88(6):323–328. doi: 10.1111/j.1699-0463.1980.tb02650.x. [DOI] [PubMed] [Google Scholar]
  2. Barnett E. V., Williams R. C., Jr, Kenyon A. J., Henson J. E. 'Nuclear' antigens and antinuclear antibodies in mink sera. Immunology. 1969 Feb;16(2):241–253. [PMC free article] [PubMed] [Google Scholar]
  3. Bloom M. E., Race R. E., Hadlow W. J., Chesebro B. Aleutian disease of mink: the antibody response of sapphire and pastel mink to Aleutian disease virus. J Immunol. 1975 Oct;115(4):1034–1037. [PubMed] [Google Scholar]
  4. Bloom M. E., Race R. E., Wolfinbarger J. B. Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. J Virol. 1982 Aug;43(2):608–616. doi: 10.1128/jvi.43.2.608-616.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cho H. J., Ingram D. G. Antigen and antibody in Aleutian disease in mink. I. Precipitation reaction by agar-gel electrophoresis. J Immunol. 1972 Feb;108(2):555–557. [PubMed] [Google Scholar]
  6. Cho H. J., Ingram D. G. Pathogenesis of aleutian disease of mink: nature of the antiglobulin reaction and elution of antibody from erythrocytes and glomeruli of infected mink. Infect Immun. 1973 Aug;8(2):264–271. doi: 10.1128/iai.8.2.264-271.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hahn E. C., Kenyon A. J. Anti-deoxyribonucleic acid antibody associated with persistent infection of mink with Aleutian disease virus. Infect Immun. 1980 Aug;29(2):452–458. doi: 10.1128/iai.29.2.452-458.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hahn E. C., Ramos L., Kenyon A. J. Properties of Aleutian disease virus assayed with feline kidney cells. Arch Virol. 1977;55(4):315–326. doi: 10.1007/BF01315053. [DOI] [PubMed] [Google Scholar]
  9. Henson J. B., Gorham J. R., Padgett G. A., Davis W. C. Pathogenesis of the glomerular lesions in aleutian disease of mink. Immunofluorescent studies. Arch Pathol. 1969 Jan;87(1):21–28. [PubMed] [Google Scholar]
  10. Izui S., Kobayakawa T., Zryd M. J., Louis J., Lambert P. H. Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice; II. Correlation between anti-DNA induction and polyclonal antibody formation by various polyclonal B lymphocyte activators. J Immunol. 1977 Dec;119(6):2157–2162. [PubMed] [Google Scholar]
  11. Leon S. A., Green A., Ehrlich G. E., Poland M., Shapiro B. Avidity of antibodies in SLE: relation to severity of renal involvement. Arthritis Rheum. 1977 Jan-Feb;20(1):23–29. doi: 10.1002/art.1780200104. [DOI] [PubMed] [Google Scholar]
  12. Lodmell D. L., Hadlow W. J., Munoz J. J., Whitford H. W. Hemagglutinin antibody response of normal and Aleutian disease-affected mink to keyhole limpet hemocyanin. J Immunol. 1970 Apr;104(4):878–887. [PubMed] [Google Scholar]
  13. PORTER D. D., DIXON F. J., LARSEN A. E. METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK. J Exp Med. 1965 Jun 1;121:889–900. doi: 10.1084/jem.121.6.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pan I. C., Tsai K. S., Karstad L. Glomerulonephritis in Aleutian disease of mink: histological and immunofluorescence studies. J Pathol. 1970 Jun;101(2):119–127. doi: 10.1002/path.1711010207. [DOI] [PubMed] [Google Scholar]
  15. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. 3. Immune complex arteritis. Am J Pathol. 1973 May;71(2):331–344. [PMC free article] [PubMed] [Google Scholar]
  16. Revie D., Tseng B. Y., Grafstrom R. H., Goulian M. Covalent association of protein with replicative form DNA of parvovirus H-1. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5539–5543. doi: 10.1073/pnas.76.11.5539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Russell A. S., Percy J. S. The antigenicity of polynucleotides in mink, rabbit, and man. J Rheumatol. 1974 Mar;1(1):66–73. [PubMed] [Google Scholar]
  18. Saison R., Karstad L., Pridham T. J. Viral plasmacytosis (Aleutian disease) in mink. VI. The development of positive Coombs test in experimental infections. Can J Comp Med Vet Sci. 1966 Jun;30(6):151–156. [PMC free article] [PubMed] [Google Scholar]
  19. Steward M. W., Katz F. E., West N. J. The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice. Clin Exp Immunol. 1975 Jul;21(1):121–130. [PMC free article] [PubMed] [Google Scholar]
  20. Tung K. S., Ellis L., Teuscher C., Meng A., Blaustein J. C., Kohno S., Howell R. The black mink (Mustela vison). A natural model of immunologic male infertility. J Exp Med. 1981 Oct 1;154(4):1016–1032. doi: 10.1084/jem.154.4.1016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wold R. T., Young F. E., Tan E. M., Farr R. S. Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid. Science. 1968 Aug 23;161(3843):806–807. doi: 10.1126/science.161.3843.806. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES