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. 1966 Jul;92(1):49–55. doi: 10.1128/jb.92.1.49-55.1966

Inhibition of Protein Synthesis by Spermine in Growing Cells of Staphylococcus aureus

Mischa E Friedman a,1, Uriel Bachrach a
PMCID: PMC276194  PMID: 5941283

Abstract

Friedman, Mischa E. (Hebrew University, Jerusalem, Israel), and Uriel Bachrach. Inhibition of protein synthesis by spermine in growing cells of Staphylococcus aureus. J. Bacteriol. 92:49–55. 1966.—Staphylococcus aureus SFL 9725 incorporated valine-C14 into cellular protein. This incorporation was inhibited by spermine when the pH of the culture was adjusted to 7.8, and the inhibition was antagonized partially by Mg++. The incorporation of C14-labeled leucine, phenylalanine, lysine, arginine, and possibly glutamic acid was inhibited to a much greater extent than that of alanine, glycine, or threonine. The uptake of spermine-C14 by S. aureus cells was rapid. More than 50% of the radioactivity resided in the soluble extract. The protein fraction of the soluble extract contained 99% of the recovered label, whereas the ribonucleic acid and deoxyribonucleic acid fractions contained little or no spermine-C14.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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