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. 1981 Aug;78(8):5056–5060. doi: 10.1073/pnas.78.8.5056

Three mouse models of human thalassemia.

J Martinell, J B Whitney 3rd, R A Popp, L B Russell, W F Anderson
PMCID: PMC320331  PMID: 6946454

Abstract

Three types of mice with globin gene mutations, called 352HB, 27HB, and Hbath-J, appear to be true animal models of human thalassemia. Expression of the alpha-globin genes in three stocks of mice, each one heterozygous for one of the alpha-globin mutations, was examined at the polypeptide, RNA, and DNA levels. alpha-Globin polypeptide chains, relative to beta-globin chains in heterozygous thalassemic mice, are present at approximately 80% of normal. The ratios of alpha-globin to beta-globin RNA sequences are also 75-80% of normal, exactly reflecting the alpha-globin to beta-globin chain ratios. In the case of mutant 352HB, at least one alpha-globin gene is deleted. Thalassemic mouse erythroid cells appear to compensate partially for the loss of half of their alpha-globin genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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