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. 1991 Jul 25;19(14):3861–3865. doi: 10.1093/nar/19.14.3861

Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID).

T Tamura 1, K Sumita 1, I Fujino 1, A Aoyama 1, M Horikoshi 1, A Hoffmann 1, R G Roeder 1, M Muramatsu 1, K Mikoshiba 1
PMCID: PMC328475  PMID: 1861978

Abstract

A complementary DNA (cDNA) encoding a mouse TFIID (mIID) was isolated from mouse brain cDNA libraries. The 316 amino acid sequence deduced from cDNA sequences revealed the presence of an amino-terminal region enriched in serine, threonine, and proline (STP-cluster), an uninterrupted stretch of 13 glutamine residues (Q-run), a second STP-cluster, and a conserved carboxy-terminal region. Amino acid sequences of the first STP-cluster and the conserved carboxy-terminal region were identical to those of the human TFIID (hIID). However, the Q-run was considerably shorter than that in hIID and sequences in the second STP-cluster diverged from those of the hIID. The murine TFIID transcript is expressed as a 2 kilobase poly(A)+ RNA in the mouse brain. Southern blot analysis identified a single gene copy per haploid mouse genome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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