Abstract
Some algorithms are described for the search of regions in a nucleic acid sequence that, when translated into amino acids, are homologous to a given amino acid pattern. All algorithms are modifications of the dynamic programming method for sequence comparison such that the translation of codons is taken into account. One of the algorithms has been implemented as a FORTRAN 77 program. The program operates on files that follow the format of the EMBL Nucleotide Sequence Data Library.
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Selected References
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- Kalkkinen N., Laaksonen M., Söderlund H., Jörnvall H. Radio-sequence analysis of in vivo multilabeled nonstructural protein ns86 of Semliki Forest, virus. Virology. 1981 Aug;113(1):188–195. doi: 10.1016/0042-6822(81)90147-1. [DOI] [PubMed] [Google Scholar]
- Needleman S. B., Wunsch C. D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J Mol Biol. 1970 Mar;48(3):443–453. doi: 10.1016/0022-2836(70)90057-4. [DOI] [PubMed] [Google Scholar]
- Peltola H., Söderlund H., Ukkonen E. SEQAID: a DNA sequence assembling program based on a mathematical model. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):307–321. doi: 10.1093/nar/12.1part1.307. [DOI] [PMC free article] [PubMed] [Google Scholar]