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. 1982 Nov;38(2):686–693. doi: 10.1128/iai.38.2.686-693.1982

Mechanism of depletion of T lymphocytes from the spleen of mice infected with Listeria monocytogenes.

Y Y Chan, C Cheers
PMCID: PMC347793  PMID: 6982869

Abstract

Marked changes in the splenic lymphocyte populations during murine infection with Listeria monocytogenes were observed histologically and quantitated by the immunofluorescence of Thy-1+ immunoglobulin (Ig-) (T) and Ig+ (B) cells. Cells were depleted from the T-dependent areas of the spleen, and the number of T cells in suspensions prepared from spleens of mice 1 to 3 days after primary or secondary infection were less than 1/10 of normal. High numbers of alcohol-killed Listeria sp. did not cause any depletion. Depletion was not prevented by adrenalectomy. Although injected radiolabeled T cells distributed normally between spleen, liver, lymph node, and gut in infected mice, there appeared to be a barrier to their entry into depleted T-dependent areas of the spleen. Evidence for the destruction of T cells, but not of B cells, in the infected mouse spleen was obtained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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