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. 1980 Oct;77(10):6047–6051. doi: 10.1073/pnas.77.10.6047

Regulation of Tn5 transposition in Salmonella typhimurium.

D Biek, J R Roth
PMCID: PMC350210  PMID: 6255475

Abstract

The drug-resistance element Tn5 transposes with high frequency immediately after entry into a cell. Establishment of Tn5 within a cell results in a decrease in this transposition frequency. This phenomenon resembles "zygotic induction" of repressible operons and prophages. Evidence is presented that Tn5 transposition is under negative control by a factor encoded within the element itself. Established Tn5 elements (that contain point mutations inactivating the resistance gene) are able to inhibit transposition of an incoming Tn5 element by a factor of 12- to 70-fold. Several deletion derivatives of Tn5 lack the ability to inhibit transposition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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