Abstract
Seven well volunteers and three patients with a naturally occurring influenza A/USSR/77 (H1N1)-like infection were given amantadine by small-particle aerosol with a Collison generator modified for this purpose. Inhalation periods for the volunteers were increased on consecutive weekends from 15 min to 1 h, 4 h, 9 h, and 2 consecutive days of 6 h each. The particle size was 1.2-micrometer mass median diameter, and the concentration of inhaled aerosol ranged from 47 to 75 microgram/liter. Estimates of retained doses in 9 h were 74 to 149 mg. About two-thirds of the dose was recovered in the urine. Pulmonary function studies did not vary significantly from base-line values and were within a normal range for five of seven volunteers. Two volunteers with a moderate reduction in mid-maximal flow before exposure had a total of three episodes of coughing and wheezing associated with moderate reductions in mid-maximal flow values. These episodes cleared spontaneously or improved promptly after isoproterenol therapy. The patients with influenza tolerated the treatment well and recovered promptly.
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- BURROWS B., KASIK J. E., NIDEN A. H., BARCLAY W. R. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am Rev Respir Dis. 1961 Dec;84:789–806. doi: 10.1164/arrd.1961.84.6.789. [DOI] [PubMed] [Google Scholar]
- Little J. W., Hall W. J., Douglas R. G., Jr, Mudholkar G. S., Speers D. M., Patel K. Airway hyperreactivity and peripheral airway dysfunction in influenza A infection. Am Rev Respir Dis. 1978 Aug;118(2):295–303. doi: 10.1164/arrd.1978.118.2.295. [DOI] [PubMed] [Google Scholar]
- Morris J. F., Koski A., Johnson L. C. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 1971 Jan;103(1):57–67. doi: 10.1164/arrd.1971.103.1.57. [DOI] [PubMed] [Google Scholar]
- Walker J. S., Stephen E. L., Spertzel R. O. Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice. J Infect Dis. 1976 Jun;133 (Suppl):A140–A144. doi: 10.1093/infdis/133.supplement_2.a140. [DOI] [PubMed] [Google Scholar]
- Wilson S. Z., Knight V., Moore R., Larson E. W. Amantadine small-particle aerosol: generation and delivery to man. Proc Soc Exp Biol Med. 1979 Jul;161(3):350–354. doi: 10.3181/00379727-161-40551. [DOI] [PubMed] [Google Scholar]
- Young H. W., Dominik J. W., Walker J. S., Larson E. W. Continuous aerosol therapy system using a modified Collison nebulizer. J Clin Microbiol. 1977 Feb;5(2):131–136. doi: 10.1128/jcm.5.2.131-136.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]