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. 1979 Jun;30(3):891–898. doi: 10.1128/jvi.30.3.891-898.1979

Multiple copies of Shope virus DNA are present in cells of benign and malignant non-virus-producing neoplasms.

J G Stevens, F O Wettstein
PMCID: PMC353400  PMID: 225548

Abstract

In an initial efforts to characterize the virological basis of neoplasia in the Shope papilloma-carcinoma system, the extent to which the viral genome is present in non-virus-producing benign and malignant tumors in domestic rabbits was established. Employing nick-translated radioactive viral DNA purified from productively infected papillomas on cotton tail rabbits as a probe, it was found that (i) papillomas, primary carcinomas, and metastatic carcinomas contain 10 to about 100 copies of the viral genome per diploid cell equivalent of DNA and (ii) viral DNA is present in detectable amounts in essentially all neoplastic cells. These results are consistent with the suggestion that continued presence of the viral genome is necessary for induction and maintenance of malignant as well as benign neoplasms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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