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. 1980 Nov;36(2):591–594. doi: 10.1128/jvi.36.2.591-594.1980

Generation of nondefective Rous sarcoma virus by asymmetric recombination between deletion mutants.

G S Martin, W H Lee, P H Duesberg
PMCID: PMC353678  PMID: 6253679

Abstract

A replication-defective deletion mutant of Prague Rous sarcoma virus (RSV), which lacks functional gag, pol, and env genes, was crossed with a transformation-defective deletion mutant derived from Schmidt-Ruppin RSV. Transformation- and replication-competent viruses were generated in the cross. Characterization of one of these rescued viruses indicated that it was a nondefective recombinant containing the src gene of the replication-defective mutant plus the replicative genes of the transformation-defective virus. These results indicate that, contrary to previous reports, asymmetric recombination between RSV deletion mutants can result in the formation of nondefective RSV.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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