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. 1980 Dec;66(6):1363–1368. doi: 10.1172/JCI109989

Polycythemia Vera

FURTHER IN VITRO STUDIES OF HEMATOPOIETIC REGULATION

John W Adamson 1,2,3,4, Jack W Singer 1,2,3,4, Pat Catalano 1,2,3,4, Scott Murphy 1,2,3,4, Nancy Lin 1,2,3,4, Laura Steinmann 1,2,3,4, Connie Ernst 1,2,3,4, Philip J Fialkow 1,2,3,4
PMCID: PMC371622  PMID: 7440720

Abstract

Further in vitro studies of hematopoietic regulation were carried out in two patients with polycythemia vera who were also heterozygotes (GdB/GdA) for glucose-6-phosphate-dehydrogenase (G-6-PD). While only G-6-PD type A was detectable in circulating erythrocytes, granulocytes and platelets, cultures of peripheral blood and marrow from one patient revealed a substantial number of G-6-PD type B erythroid burst-forming units (BFU-E) and granulocyte/macrophage colony-forming units. Detailed analysis demonstrated: (a) where detectable, normal BFU-E and granulocyte/macrophage colony-forming units were found with similar frequencies; (b) the same frequencies for normal progenitors characterized cultures of peripheral blood and marrow; (c) inhibition of normal erythroid differentiation between BFU-E and the more mature erythroid colony-forming unit; (d) a decline in the prevalence of normal colony-forming units with time, suggesting that disease progression is associated with further suppression of normal hematopoiesis by products of the abnormal clone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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