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. 1972 Jan;23(1):130–134. doi: 10.1128/am.23.1.130-134.1972

Reproducible Topical Staphylococcal Infection in Rats1

Faith Goldschmidt a
PMCID: PMC380290  PMID: 5059616

Abstract

A topical infection model for the study of the effectiveness of antimicrobials was developed. Animals were laparotomized, sutured with braided silk, and inoculated with a strain of Staphylococcus aureus. The test organism was phage typed, and its antibiotic spectrum was determined. Concentrations of bacteria from 5 × 104 to 108 cells per incision produced large body wall stitch abscesses with occasional drainage through the skin. This laparotomy infection is readily reproducible and can be used for evaluation of the ability of topical antimicrobials to prevent S. aureus stitch abscesses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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