Abstract
The nature of stable equilibrium configurations is described for general nonepistatic and generalized symmetric viability regimes in multilocus systems under conditions of tight and loose linkage. The influence of epistasis and symmetry can be better understood in terms of these standards. A dichotomy in the nature of stable polymorphisms emerges. More recombination, bisexuality, and multideme interactions facilitate the establishment of central type polymorphisms.
Keywords: linkage, nonepistasis, symmetric selection, multilocus Hardy-Weinberg equilibrium, gametic and allelic polymorphisms
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coyne J. A. Lack of genic similarity between two sibling species of drosophila as revealed by varied techniques. Genetics. 1976 Nov;84(3):593–607. doi: 10.1093/genetics/84.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldman M. W., Franklin I., Thomson G. J. Selection in complex genetic systems. I. The symmetric equilibria of the three-locus symmetric viability model. Genetics. 1974 Jan;76(1):135–162. doi: 10.1093/genetics/76.1.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Franklin I., Lewontin R. C. Is the gene the unit of selection? Genetics. 1970 Aug;65(4):707–734. doi: 10.1093/genetics/65.4.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S., Feldman M. W. Simultaneous Stability of D=0 and D not equal0 for Multiplicative Viabilities at Two Loci. Genetics. 1978 Dec;90(4):813–825. doi: 10.1093/genetics/90.4.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S., Liberman U. Classifications and comparisons of multilocus recombination distributions. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6332–6336. doi: 10.1073/pnas.75.12.6332. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S., McGregor J. Application of method of small parameters to multi-niche population genetic models. Theor Popul Biol. 1972 Jun;3(2):186–209. doi: 10.1016/0040-5809(72)90026-3. [DOI] [PubMed] [Google Scholar]
- Singh R. S., Lewontin R. C., Felton A. A. Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics. 1976 Nov;84(3):609–629. doi: 10.1093/genetics/84.3.609. [DOI] [PMC free article] [PubMed] [Google Scholar]