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. 1979 Apr;24(1):117–120. doi: 10.1128/iai.24.1.117-120.1979

Thymus-dependent control of host defense mechanisms against Trypanosoma cruzi infection.

F Kierszenbaum, M M Pienkowski
PMCID: PMC414271  PMID: 110686

Abstract

Congenitally athymic homozygous (nu/nu) mice were shown to be significantly more susceptible to Trypanosoma cruzi infection than their thymus-bearing heterozygous (nu/+) littermates, as measured by increased parasitemia, mortality rate, and shortened survival time. In addition, transplantation of neonatal thymus into athymic mice reestablished normal levels of resistance to T. cruzi, i.e., comparable to those of normal littermates. These results constitute conclusive evidence that host defense mechanisms active in experimental Chagas' disease are under thymic control.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Budzko D. B., Pizzimenti M. C., Kierszenbaum F. Effects of complement depletion in experimental chagas disease: immune lysis of virulent blood forms of Trypanosoma cruzi. Infect Immun. 1975 Jan;11(1):86–91. doi: 10.1128/iai.11.1.86-91.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Campbell G. H., Esser K. M., Phillips S. M. Trypanosoma rhodesiense infection in congenitally athymic (nude) mice. Infect Immun. 1978 Jun;20(3):714–720. doi: 10.1128/iai.20.3.714-720.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dvorak J. A., Schmunis G. A. Trypanosoma cruzi: interaction with mouse peritoneal macrophages. Exp Parasitol. 1972 Oct;32(2):289–300. doi: 10.1016/0014-4894(72)90036-7. [DOI] [PubMed] [Google Scholar]
  4. KAGAN I. G., NORMAN L. Immunologic studies on Trypanosoma cruzi. III. Duration of acquired immunity in mice initially infected with a North American strain of T. cruzi. J Infect Dis. 1961 Mar-Apr;108:213–217. doi: 10.1093/infdis/108.2.213. [DOI] [PubMed] [Google Scholar]
  5. Kierszenbaum F., Budzko D. B. Immunization against experimental Chagas' disease by using culture forms of Trypanosoma cruzi killed with a solution of sodium perchlorate. Infect Immun. 1975 Sep;12(3):461–465. doi: 10.1128/iai.12.3.461-465.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kierszenbaum F. Cross-reactivity of lytic antibodies against blood forms of Trypanosoma cruzi. J Parasitol. 1976 Feb;62(1):134–135. [PubMed] [Google Scholar]
  7. Kierszenbaum F., Howard J. G. Mechanisms of resistance against experimental Trypanosoma cruzi infection: the importance of antibodies and antibody-forming capacity in the Biozzi high and low responder mice. J Immunol. 1976 May;116(5):1208–1211. [PubMed] [Google Scholar]
  8. Kierszenbaum F., Knecht E., Budzko D. B., Pizzimenti M. C. Phagocytosis: a defense mechanism against infection with Trypanosoma cruzi. J Immunol. 1974 May;112(5):1839–1844. [PubMed] [Google Scholar]
  9. Kierszenbaum F., Saavedra L. E. The effects of bacterial endotoxin on the infection of mice with Trypanosoma cruzi. J Protozool. 1972 Nov;19(4):655–657. doi: 10.1111/j.1550-7408.1972.tb03552.x. [DOI] [PubMed] [Google Scholar]
  10. Kindred B., Loor F. Survival and activity of congenic and allogeneic thymus cell suspensions in nude mice. Cell Immunol. 1975 Apr;16(2):432–438. doi: 10.1016/0008-8749(75)90133-1. [DOI] [PubMed] [Google Scholar]
  11. Kindred B., Shreffler D. C. H-2 dependence of co-operation between T and B cells in vivo. J Immunol. 1972 Nov;109(5):940–943. [PubMed] [Google Scholar]
  12. Kuhn R. E., Durum S. K. The onset of immune protection in acute experimental Chagas' disease in C3H(HE) mice. Int J Parasitol. 1975 Apr;5(2):241–244. doi: 10.1016/0020-7519(75)90113-7. [DOI] [PubMed] [Google Scholar]
  13. Kumar R., Kline I. K., Abelmann W. H. Immunosuppression in experimental acute and subacute Chagasic myocarditis. Am J Trop Med Hyg. 1970 Nov;19(6):932–939. doi: 10.4269/ajtmh.1970.19.932. [DOI] [PubMed] [Google Scholar]
  14. Lelchuk R., Patrucco A., Manni J. A. Studies of cellular immunity in Chagas disease: effect of glutaraldehyde-treated specific antigen on inhibition of leukocyte migration. J Immunol. 1974 Apr;112(4):1578–1581. [PubMed] [Google Scholar]
  15. McHardy N. Passive immunization of mice against Trypanosoma cruzi using convalescent mouse serum. Tropenmed Parasitol. 1977 Jun;28(2):195–201. [PubMed] [Google Scholar]
  16. McManus M. J., Dembroske S. E., Pienkowski M. M., Anderson T. J., Mann L. C., Schuster J. S., Vollwiler L. L., Weisch C. U. Successful transplantation of human benign breast tumors into the athymic nude mouse and demonstration of enhanced DNA synthesis by human placental lactogen. Cancer Res. 1978 Aug;38(8):2343–2349. [PubMed] [Google Scholar]
  17. Pienkowski M. M., Lyerly M. M., Miller H. C. Rapid lymphocyte immunoreactivity test utilizing [3H]uridine in vitro. J Immunol Methods. 1978;24(1-2):163–173. doi: 10.1016/0022-1759(78)90097-2. [DOI] [PubMed] [Google Scholar]
  18. Pienkowski M. M., Rosloniec E. F., Jr, Myers R., Welsch C. W. A visual display board used for efficient breeding and utilization of an athymic (nude) mouse colony. Lab Anim Sci. 1979 Feb;29(1):71–73. [PubMed] [Google Scholar]
  19. Roberson E. L., Chapman W. L., Jr, Hanson W. L. The effects of total-body x-irradiation on Trypanosoma cruzi infection (Chagas' disease) in mice and rats. Z Parasitenkd. 1973 Apr 24;41(2):83–94. doi: 10.1007/BF00328752. [DOI] [PubMed] [Google Scholar]
  20. Roberson E. L., Hanson W. L. Correspondence: Transfer of immunity to T. cruzi. Trans R Soc Trop Med Hyg. 1974;68(4):338–338. doi: 10.1016/0035-9203(74)90044-3. [DOI] [PubMed] [Google Scholar]
  21. Roberson E. L., Hanson W. L. Trypanosoma cruzi: effects of anti-thymocyte serum in mice and neonatal thymectomy in rats. Exp Parasitol. 1973 Oct;34(2):168–180. doi: 10.1016/0014-4894(73)90076-3. [DOI] [PubMed] [Google Scholar]
  22. Sanderson C. J., Lopez A. F., Moreno M. M. Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes. Nature. 1977 Jul 28;268(5618):340–341. doi: 10.1038/268340a0. [DOI] [PubMed] [Google Scholar]
  23. Santos-Buch C. A., Teixeira A. R. The immunology of experimental Chagas' disease. 3. Rejection of allogeneic heart cells in vitro. J Exp Med. 1974 Jul 1;140(1):38–53. doi: 10.1084/jem.140.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Schmuñis G. A., Vattuone H., Szarfman A., Pesce U. J. Cell mediated immunity in mice innoculated with epimastigotes or trypomastigotes or Trypanosoma cruzi. Z Tropenmed Parasitol. 1973 Mar;24(1):81–85. [PubMed] [Google Scholar]
  25. Seah S. Delayed hypersensitivity in Trypanosoma cruzi infection. Nature. 1970 Mar 28;225(5239):1256–1257. doi: 10.1038/2251256a0. [DOI] [PubMed] [Google Scholar]
  26. Splitter G. A., McGuire T. C., Davis W. C. The differentiation of bone marrow cells to functional T lymphocytes following implantation of thymus grafts and thymic stroma in nude and ATxBM mice. Cell Immunol. 1977 Nov;34(1):93–103. doi: 10.1016/0008-8749(77)90232-5. [DOI] [PubMed] [Google Scholar]
  27. TALIAFERRO W. H., PIZZI T. Connective tissue reactions in normal and immunized mice to a reticulotropic strain of Trypanosoma cruzi. J Infect Dis. 1955 May-Jun;96(3):199–226. doi: 10.1093/infdis/96.3.199. [DOI] [PubMed] [Google Scholar]
  28. Tschudi E. I., Anziano D. F., Dalmasso A. P. Lymphocyte transformation in Chagas disease. Infect Immun. 1972 Dec;6(6):905–908. doi: 10.1128/iai.6.6.905-908.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Williams D. M., Remington J. S. Effect of human monocytes and macrophages on Trypanosoma cruzi. Immunology. 1977 Jan;32(1):19–23. [PMC free article] [PubMed] [Google Scholar]
  30. Wortis H. H. Immunological responses of 'nude' mice. Clin Exp Immunol. 1971 Feb;8(2):305–317. [PMC free article] [PubMed] [Google Scholar]

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