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. 1979 May;24(2):308–312. doi: 10.1128/iai.24.2.308-312.1979

Inhibition of macrophage migration by muramyl peptides.

S Nagao, A Tanaka, Y Yamamoto, T Koga, K Onoue, T Shiba, K Kusumoto, S Kotani
PMCID: PMC414302  PMID: 457276

Abstract

In the capillary tube migration system a synthetic muramyl dipeptide (MDP; N-acetylmuramyl-L-alanyl-D-isoglutamine), a part of bacterial cell wall peptidoglycans, inhibited the migration of peritoneal exudate macrophages from normal guinea pigs or rats. The migration inhibition was also caused by some MDP-containing peptidoglycan fragments from cell walls of Lactobacillus plantarum and Staphylococcus epidermidis. The migration inhibition could not be explained on the basis of macrophage migration inhibitory factor. A stereochemically highly specific structure of MDP required for its adjuvant activity was also required for the macrophage migration inhibition. These findings suggest that MDP and MDP-containing cell wall fragments may activate macrophages and that this activation may be important in the exertion of their adjuvant activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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