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. 1974 May;9(5):939–945. doi: 10.1128/iai.9.5.939-945.1974

Some Physiological and Biochemical Effects of a Coxiella burneti Lipopolysaccharide Preparation on Guinea Pigs

O G Baca a,1, D Paretsky a
PMCID: PMC414910  PMID: 4596281

Abstract

A lipopolysaccharide obtained in a dialyzed phenol extract from the rickettsia Coxiella burneti produced the following effects in guinea pigs after intraperitoneal injection: hyperthermia, loss of body weight, increased liver weight and concomitant lipid infiltration, elevated levels of hepatic and plasma cortisol, increased incorporation of [3H]orotic acid into hepatic 28S and 18S ribosomal ribonucleic acid, increased incorporation of 14C-labeled amino acids into liver and plasma protein, and leukocytosis. Most of these events also occur during infection of guinea pigs with C. burneti, and a causal relationship between the rickettsial lipopolysaccharide and the biochemical changes that occur during Q fever is suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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