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. 1971 May;3(5):694–701. doi: 10.1128/iai.3.5.694-701.1971

Relationships Between Mycoplasma pneumoniae and Human Respiratory Epithelium

Albert M Collier 1, Wallace A Clyde Jr 1
PMCID: PMC416218  PMID: 16558038

Abstract

The interaction was studied between Mycoplasma pneumoniae and its natural host cell, the human respiratory epithelium. Organized, ciliated cells provided by fetal trachea in organ culture enabled examination of the host-parasite relationship by light, immunofluorescence, and electron microscopy. Impairment of cellular function was reflected by disorganization and loss of ciliary motion; this was associated with a sequence of cytopathological changes denoting progressive cell injury. The organisms were found concentrated on the luminal surface of ciliated epithelium and cells lining the submucosal glands. A differentiated portion of the Mycoplasma, consisting of an extension of the unit membrane containing an electron-dense core surrounded by a lucent space, served as the means of attachment to host cells. The findings suggest that the pathogenicity of M. pneumoniae depends upon intimate extracellular infection with production of functional and structural changes initiated by host cell membrane injury.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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