Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1978 Oct;22(1):69–71. doi: 10.1128/iai.22.1.69-71.1978

Experimental Q fever infection in congenitally athymic nude mice.

R A Kishimoto, H Rozmiarek, E W Larson
PMCID: PMC422117  PMID: 730352

Abstract

Congenitally athymic nude (nu/nu) mice and their phenotypically normal (nu/+) euthymic littermates were exposed to Coxiella burnetii administered as small-particle aerosols. After challenge, both strains of mice became infected, as characterized by rickettsemia, viable rickettsiae in the spleen, and serological conversion. The major difference noted was that euthymic animals had cleared rickettsiae from peripheral circulation and the spleen within 14 days. In contrast, rickettsiae were detected and isolated from spleen and blood of athymic mice through 60 days.

Full text

PDF
71

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABINANTI F. R., MARMION B. P. Protective or neutralizing antibody in Q fever. Am J Hyg. 1957 Sep;66(2):173–195. doi: 10.1093/oxfordjournals.aje.a119894. [DOI] [PubMed] [Google Scholar]
  2. BOZEMAN F. M., ELISBERG B. L. Serological diagnosis of scrub typhus by indirect immunofluorescence. Proc Soc Exp Biol Med. 1963 Mar;112:568–573. doi: 10.3181/00379727-112-28107. [DOI] [PubMed] [Google Scholar]
  3. Cheers C., Waller R. Activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice. J Immunol. 1975 Sep;115(3):844–847. [PubMed] [Google Scholar]
  4. Clark I. A., Allison A. C. Babesia microti and Plasmodium berghei yoelii infections in nude mice. Nature. 1974 Nov 22;252(5481):328–329. doi: 10.1038/252328a0. [DOI] [PubMed] [Google Scholar]
  5. Emmerling P., Finger H., Bockemühl J. Listeria monocytogenes infection in nude mice. Infect Immun. 1975 Aug;12(2):437–439. doi: 10.1128/iai.12.2.437-439.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GIMENEZ D. F. STAINING RICKETTSIAE IN YOLK-SAC CULTURES. Stain Technol. 1964 May;39:135–140. doi: 10.3109/10520296409061219. [DOI] [PubMed] [Google Scholar]
  7. Hahon N., Cooke K. O. Assay of Coxiella burnetii by enumeration of immunofluorescent infected cells. J Immunol. 1966 Oct;97(4):492–497. doi: 10.21236/ad0482256. [DOI] [PubMed] [Google Scholar]
  8. Hinrichs D. J., Jerrells T. R. In vitro evaluation of immunity to Coxiella burnetii. J Immunol. 1976 Sep;117(3):996–1003. [PubMed] [Google Scholar]
  9. Holub M., Rossmann P., Tlaskalova H., Vidmarova H. Thymus rudiment of the athymic nude mouse. Nature. 1975 Aug 7;256(5517):491–493. doi: 10.1038/256491a0. [DOI] [PubMed] [Google Scholar]
  10. Kazár J., El-Najdawi E., Brezina R., Schramek S. Search for correlates of resistance to virulent challenge in mice immunized with Coxiella burnetii. Acta Virol. 1977 Sep;21(5):422–430. [PubMed] [Google Scholar]
  11. Kishimoto R. A., Burger G. T. Appearance of cellular and humoral immunity in guinea pigs after infection with Coxiella burnetii administered in small-particle aerosols. Infect Immun. 1977 May;16(2):518–521. doi: 10.1128/iai.16.2.518-521.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kishimoto R. A., Veltri B. J., Canonico P. G., Shirey F. G., Walker J. S. Electron microscopic study on the interaction between normal guinea pig peritoneal macrophages and Coxiella burnetii. Infect Immun. 1976 Oct;14(4):1087–1096. doi: 10.1128/iai.14.4.1087-1096.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kishimoto R. A., Walker J. S. Interaction between Coxiella burnetii and guinea pig peritoneal macrophages. Infect Immun. 1976 Aug;14(2):416–421. doi: 10.1128/iai.14.2.416-421.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Krahenbuhl J. L., Remington J. S. In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes. Infect Immun. 1971 Oct;4(4):337–343. doi: 10.1128/iai.4.4.337-343.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Loor F., Roelants G. E. High frequency of T lineage lymphocytes in nude mouse spleen. Nature. 1974 Sep 20;251(5472):229–230. doi: 10.1038/251229a0. [DOI] [PubMed] [Google Scholar]
  16. Pantelouris E. M. Absence of thymus in a mouse mutant. Nature. 1968 Jan 27;217(5126):370–371. doi: 10.1038/217370a0. [DOI] [PubMed] [Google Scholar]
  17. Pantelouris E. M. Observations on the immunobiology of 'nude' mice. Immunology. 1971 Feb;20(2):247–252. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES