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. 1973 May;7(5):718–724. doi: 10.1128/iai.7.5.718-724.1973

Ribonucleic Acid and Protein Synthesis in Guinea Pig Liver During Q Fever

H A Thompson a,1, D Paretsky a
PMCID: PMC422750  PMID: 4764402

Abstract

Protein and ribonucleic acid (RNA) syntheses increase in the liver during Q fever, coincident with progressive increments in cortisol levels. Cell-free protein-synthesizing systems indicate that the pH 5 enzyme fraction was chiefly responsible for enhanced activity. Although the polysome profiles from normal and infected livers were similar, the number of liver ribosomes doubled during infection. There was a concomitant increase in orotate incorporation in the 28s, 18s, and 4s RNA species of infected liver.

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Selected References

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