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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1995 Mar 28;92(7):2710–2714. doi: 10.1073/pnas.92.7.2710

A random-walk/giant-loop model for interphase chromosomes.

R K Sachs 1, G van den Engh 1, B Trask 1, H Yokota 1, J E Hearst 1
PMCID: PMC42288  PMID: 7708711

Abstract

Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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