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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1972 Feb;69(2):363–365. doi: 10.1073/pnas.69.2.363

Activity of Ribosomes Containing 5S RNA with a Chemically Modified 3′-Terminus*

S R Fahnestock 1,2,3, M Nomura 1,2,3
PMCID: PMC426458  PMID: 4333979

Abstract

Ribosomes containing 5S RNA in which the 3′-terminus has been modified chemically, either by periodate oxidation or by conversion of the terminal ribose to a morpholine derivative, are fully as active in peptidebond formation and polypeptide synthesis as those ribosomes with unmodified 5S RNA. These results exclude models for protein synthesis in which peptidyl-5S RNA is formed as an intermediate.

Keywords: B. stearothermophilus, peptidyl-tRNA, periodate, morpholine derivative, protein synthesis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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