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. 1977 Aug;12(2):298–300. doi: 10.1128/aac.12.2.298

Cytotoxicity and Cell Cycle Specificity of Homoharringtonine

D M Baaske 1, Peter Heinstein 1
PMCID: PMC429904  PMID: 900926

Abstract

The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G1 and G2 phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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