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. 1975 Feb;72(2):628–632. doi: 10.1073/pnas.72.2.628

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.

C C Tsai, S C Jain, H M Sobell
PMCID: PMC432367  PMID: 1054844

Abstract

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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