Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1973 Mar;70(3):747–749. doi: 10.1073/pnas.70.3.747

Protective Effect of Ascorbic Acid on Hepatotoxicity Caused by Sodium Nitrite Plus Aminopyrine

Jerome J Kamm 1, Theodore Dashman 1, A H Conney 1, J J Burns 1
PMCID: PMC433349  PMID: 4514987

Abstract

The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.

Keywords: rats, serum alanine aminotransferase

Full text

PDF
748

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Lam Y., Nicholas D. J. A nitrate reductase from Micrococcus denitrificans. Biochim Biophys Acta. 1969 Apr 22;178(2):225–234. doi: 10.1016/0005-2744(69)90392-1. [DOI] [PubMed] [Google Scholar]
  2. Lijinsky W., Epstein S. S. Nitrosamines as environmental carcinogens. Nature. 1970 Jan 3;225(5227):21–23. doi: 10.1038/225021a0. [DOI] [PubMed] [Google Scholar]
  3. Lijinsky W., Greenblatt M. Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine. Nat New Biol. 1972 Apr 12;236(67):177–178. doi: 10.1038/newbio236177a0. [DOI] [PubMed] [Google Scholar]
  4. Magee P. N., Barnes J. M. Carcinogenic nitroso compounds. Adv Cancer Res. 1967;10:163–246. doi: 10.1016/s0065-230x(08)60079-2. [DOI] [PubMed] [Google Scholar]
  5. Magee P. N. Toxicity of nitrosamines: their possible human health hazards. Food Cosmet Toxicol. 1971 Apr;9(2):207–218. doi: 10.1016/0015-6264(71)90306-3. [DOI] [PubMed] [Google Scholar]
  6. Mirvish S. S., Wallcave L., Eagen M., Shubik P. Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds. Science. 1972 Jul 7;177(4043):65–68. doi: 10.1126/science.177.4043.65. [DOI] [PubMed] [Google Scholar]
  7. NASON A. Symposium on metabolism of inorganic compounds. II. Enzymatic pathways of nitrate, nitrite, and hydroxylamine metabolisms. Bacteriol Rev. 1962 Mar;26:16–41. doi: 10.1128/br.26.1.16-41.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Wolff I. A., Wasserman A. E. Nitrates, nitrites, and nitrosamines. Science. 1972 Jul 7;177(4043):15–19. doi: 10.1126/science.177.4043.15. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES