Skip to main content
Thorax logoLink to Thorax
. 1986 Sep;41(9):657–662. doi: 10.1136/thx.41.9.657

Role of inflammation in the hyperreactivity of the airways in asthma.

K F Chung
PMCID: PMC460425  PMID: 3538489

Full text

PDF
659

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman S. J., Loegering D. A., Venge P., Olsson I., Harley J. B., Fauci A. S., Gleich G. J. Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin. J Immunol. 1983 Dec;131(6):2977–2982. [PubMed] [Google Scholar]
  2. Armour C. L., Lazar N. M., Schellenberg R. R., Taylor S. M., Chan N., Hogg J. C., Paré P. D. A comparison of in vivo and in vitro human airway reactivity to histamine. Am Rev Respir Dis. 1984 Jun;129(6):907–910. doi: 10.1164/arrd.1984.129.6.907. [DOI] [PubMed] [Google Scholar]
  3. Arnoux B., Duval D., Benveniste J. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. Eur J Clin Invest. 1980 Dec;10(6):437–441. doi: 10.1111/j.1365-2362.1980.tb02082.x. [DOI] [PubMed] [Google Scholar]
  4. Barnes P. J. Asthma as an axon reflex. Lancet. 1986 Feb 1;1(8475):242–245. doi: 10.1016/s0140-6736(86)90777-4. [DOI] [PubMed] [Google Scholar]
  5. Barnes P. J., Cuss F. M., Palmer J. B. The effect of airway epithelium on smooth muscle contractility in bovine trachea. Br J Pharmacol. 1985 Nov;86(3):685–691. doi: 10.1111/j.1476-5381.1985.tb08946.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Boulet L. P., Latimer K. M., Roberts R. S., Juniper E. F., Cockcroft D. W., Thomson N. C., Daniel E. E., Hargreave F. E. The effect of atropine on allergen-induced increases in bronchial responsiveness to histamine. Am Rev Respir Dis. 1984 Sep;130(3):368–372. doi: 10.1164/arrd.1984.130.3.368. [DOI] [PubMed] [Google Scholar]
  7. Boushey H. A., Holtzman M. J., Sheller J. R., Nadel J. A. Bronchial hyperreactivity. Am Rev Respir Dis. 1980 Feb;121(2):389–413. doi: 10.1164/arrd.1980.121.2.389. [DOI] [PubMed] [Google Scholar]
  8. Cartier A., Thomson N. C., Frith P. A., Roberts R., Hargreave F. E. Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol. 1982 Sep;70(3):170–177. doi: 10.1016/0091-6749(82)90038-0. [DOI] [PubMed] [Google Scholar]
  9. Chung K. F., Aizawa H., Leikauf G. D., Ueki I. F., Evans T. W., Nadel J. A. Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther. 1986 Mar;236(3):580–584. [PubMed] [Google Scholar]
  10. Chung K. F., Becker A. B., Lazarus S. C., Frick O. L., Nadel J. A., Gold W. M. Antigen-induced airway hyperresponsiveness and pulmonary inflammation in allergic dogs. J Appl Physiol (1985) 1985 Apr;58(4):1347–1353. doi: 10.1152/jappl.1985.58.4.1347. [DOI] [PubMed] [Google Scholar]
  11. Chung K. F., Evans T. W., Graf P. D., Nadel J. A. Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619. Eur J Pharmacol. 1985 Nov 19;117(3):373–375. doi: 10.1016/0014-2999(85)90012-3. [DOI] [PubMed] [Google Scholar]
  12. Cockcroft D. W., Ruffin R. E., Dolovich J., Hargreave F. E. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy. 1977 Nov;7(6):503–513. doi: 10.1111/j.1365-2222.1977.tb01481.x. [DOI] [PubMed] [Google Scholar]
  13. Copas J. L., Borgeat P., Gardiner P. J. The actions of 5-, 12-, and 15-HETE on tracheobronchial smooth muscle. Prostaglandins Leukot Med. 1982 Feb;8(2):105–114. doi: 10.1016/s0262-1746(82)80002-4. [DOI] [PubMed] [Google Scholar]
  14. Creese B. R., Bach M. K. Hyperreactivity of airways smooth muscle produced in vitro by leukotrienes. Prostaglandins Leukot Med. 1983 Jun;11(2):161–169. doi: 10.1016/0262-1746(83)90016-1. [DOI] [PubMed] [Google Scholar]
  15. Cuypers H. T., van Loon-Klaassen L. A., Egberts W. T., de Jong W. W., Bloemendal H. Sulfhydryl content of bovine eye lens leucine aminopeptidase. Determination of the reactivity of the sulfhydryl groups of the zinc metalloenzyme, of the enzyme activated by Mg2+, Mn2+, and Co2+, and of the metal-free apoenzyme. J Biol Chem. 1982 Jun 25;257(12):7086–7091. [PubMed] [Google Scholar]
  16. DUNNILL M. S. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol. 1960 Jan;13:27–33. doi: 10.1136/jcp.13.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. De Monchy J. G., Kauffman H. F., Venge P., Koëter G. H., Jansen H. M., Sluiter H. J., De Vries K. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis. 1985 Mar;131(3):373–376. doi: 10.1164/arrd.1985.131.3.373. [DOI] [PubMed] [Google Scholar]
  18. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  19. Fabbri L. M., Aizawa H., Alpert S. E., Walters E. H., O'Byrne P. M., Gold B. D., Nadel J. A., Holtzman M. J. Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs. Am Rev Respir Dis. 1984 Feb;129(2):288–291. [PubMed] [Google Scholar]
  20. Fairfax A. J., Hanson J. M., Morley J. The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism. Clin Exp Immunol. 1983 May;52(2):393–398. [PMC free article] [PubMed] [Google Scholar]
  21. Filley W. V., Holley K. E., Kephart G. M., Gleich G. J. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet. 1982 Jul 3;2(8288):11–16. doi: 10.1016/s0140-6736(82)91152-7. [DOI] [PubMed] [Google Scholar]
  22. Flavahan N. A., Aarhus L. L., Rimele T. J., Vanhoutte P. M. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol (1985) 1985 Mar;58(3):834–838. doi: 10.1152/jappl.1985.58.3.834. [DOI] [PubMed] [Google Scholar]
  23. Flint K. C., Leung K. B., Hudspith B. N., Brostoff J., Pearce F. L., Johnson N. M. Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. Br Med J (Clin Res Ed) 1985 Oct 5;291(6500):923–926. doi: 10.1136/bmj.291.6500.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Freedman B. J. The functional geometry of the bronchi. The relationship between changes in external diameter and calibre, and a consideration of the passive role played by the mucosa in bronchoconstriction. Bull Physiopathol Respir (Nancy) 1972 May-Jun;8(3):545–552. [PubMed] [Google Scholar]
  25. GLYNN A. A., MICHAELS L. Bronchial biopsy in chronic bronchitis and asthma. Tip Fak Mecm. 1960 Jun;23:142–153. doi: 10.1136/thx.15.2.142. [DOI] [PubMed] [Google Scholar]
  26. Gleich G. J., Frigas E., Loegering D. A., Wassom D. L., Steinmuller D. Cytotoxic properties of the eosinophil major basic protein. J Immunol. 1979 Dec;123(6):2925–2927. [PubMed] [Google Scholar]
  27. Godard P., Chaintreuil J., Damon M., Coupe M., Flandre O., Crastes de Paulet A., Michel F. B. Functional assessment of alveolar macrophages: comparison of cells from asthmatics and normal subjects. J Allergy Clin Immunol. 1982 Aug;70(2):88–93. doi: 10.1016/0091-6749(82)90234-2. [DOI] [PubMed] [Google Scholar]
  28. Goetzl E. J., Phillips M. J., Gold W. M. Stimulus specificity of the generation of leukotrienes by dog mastocytoma cells. J Exp Med. 1983 Sep 1;158(3):731–737. doi: 10.1084/jem.158.3.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Golden J. A., Nadel J. A., Boushey H. A. Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis. 1978 Aug;118(2):287–294. doi: 10.1164/arrd.1978.118.2.287. [DOI] [PubMed] [Google Scholar]
  30. Gordon T., Sheppard D., McDonald D. M., Distefano S., Scypinski L. Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1985 Nov;132(5):1106–1112. doi: 10.1164/arrd.1985.132.5.1106. [DOI] [PubMed] [Google Scholar]
  31. Gosset P., Tonnel A. B., Joseph M., Prin L., Mallart A., Charon J., Capron A. Secretion of a chemotactic factor for neutrophils and eosinophils by alveolar macrophages from asthmatic patients. J Allergy Clin Immunol. 1984 Dec;74(6):827–834. doi: 10.1016/0091-6749(84)90186-6. [DOI] [PubMed] [Google Scholar]
  32. HOUSTON J. C., DE NAVASQUEZ S., TROUNCE J. R. A clinical and pathological study of fatal cases of status asthmaticus. Thorax. 1953 Sep;8(3):207–213. doi: 10.1136/thx.8.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Hahn H. L., Wilson A. G., Graf P. D., Fischer S. P., Nadel J. A. Interaction between serotonin and efferent vagus nerves in dog lungs. J Appl Physiol Respir Environ Exerc Physiol. 1978 Feb;44(2):144–149. doi: 10.1152/jappl.1978.44.2.144. [DOI] [PubMed] [Google Scholar]
  34. Hogg J. C. Bronchial mucosal permeability and its relationship to airways hyperreactivity. J Allergy Clin Immunol. 1981 Jun;67(6):421–425. doi: 10.1016/0091-6749(81)90094-4. [DOI] [PubMed] [Google Scholar]
  35. Holtzman M. J., Aizawa H., Nadel J. A., Goetzl E. J. Selective generation of leukotriene B4 by tracheal epithelial cells from dogs. Biochem Biophys Res Commun. 1983 Aug 12;114(3):1071–1076. doi: 10.1016/0006-291x(83)90671-x. [DOI] [PubMed] [Google Scholar]
  36. Holtzman M. J., Fabbri L. M., O'Byrne P. M., Gold B. D., Aizawa H., Walters E. H., Alpert S. E., Nadel J. A. Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis. 1983 Jun;127(6):686–690. doi: 10.1164/arrd.1983.127.6.686. [DOI] [PubMed] [Google Scholar]
  37. Hulbert W. M., McLean T., Hogg J. C. The effect of acute airway inflammation on bronchial reactivity in guinea pigs. Am Rev Respir Dis. 1985 Jul;132(1):7–11. doi: 10.1164/arrd.1985.132.1.7. [DOI] [PubMed] [Google Scholar]
  38. Hunninghake G. W., Gallin J. I., Fauci A. S. Immunologic reactivity of the lung: the in vivo and in vitro generation of a neutrophil chemotactic factor by alveolar macrophages. Am Rev Respir Dis. 1978 Jan;117(1):15–23. doi: 10.1164/arrd.1978.117.1.15. [DOI] [PubMed] [Google Scholar]
  39. Hunter J. A., Finkbeiner W. E., Nadel J. A., Goetzl E. J., Holtzman M. J. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A. 1985 Jul;82(14):4633–4637. doi: 10.1073/pnas.82.14.4633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Joseph M., Tonnel A. B., Torpier G., Capron A., Arnoux B., Benveniste J. Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients. J Clin Invest. 1983 Feb;71(2):221–230. doi: 10.1172/JCI110762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Juniper E. F., Frith P. A., Hargreave F. E. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax. 1981 Aug;36(8):575–579. doi: 10.1136/thx.36.8.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Laitinen L. A., Heino M., Laitinen A., Kava T., Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985 Apr;131(4):599–606. doi: 10.1164/arrd.1985.131.4.599. [DOI] [PubMed] [Google Scholar]
  43. Lee H. K., Murlas C. Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin. Am Rev Respir Dis. 1985 Nov;132(5):1005–1009. doi: 10.1164/arrd.1985.132.5.1005. [DOI] [PubMed] [Google Scholar]
  44. Lee L. Y., Bleecker E. R., Nadel J. A. Effect of ozone on bronchomotor response to inhaled histamine aerosol in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):626–631. doi: 10.1152/jappl.1977.43.4.626. [DOI] [PubMed] [Google Scholar]
  45. Lee T., Lenihan D. J., Malone B., Roddy L. L., Wasserman S. I. Increased biosynthesis of platelet-activating factor in activated human eosinophils. J Biol Chem. 1984 May 10;259(9):5526–5530. [PubMed] [Google Scholar]
  46. Lellouch-Tubiana A., Lefort J., Pirotzky E., Vargaftig B. B., Pfister A. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. Br J Exp Pathol. 1985 Jun;66(3):345–355. [PMC free article] [PubMed] [Google Scholar]
  47. Marsh W. R., Irvin C. G., Murphy K. R., Behrens B. L., Larsen G. L. Increases in airway reactivity to histamine and inflammatory cells in bronchoalveolar lavage after the late asthmatic response in an animal model. Am Rev Respir Dis. 1985 Jun;131(6):875–879. doi: 10.1164/arrd.1985.131.6.875. [DOI] [PubMed] [Google Scholar]
  48. Metzger W. J., Hunninghake G. W., Richerson H. B. Late asthmatic responses: inquiry into mechanisms and significance. Clin Rev Allergy. 1985 May;3(2):145–165. doi: 10.1007/BF02992980. [DOI] [PubMed] [Google Scholar]
  49. Murlas C. G., Roum J. H. Sequence of pathologic changes in the airway mucosa of guinea pigs during ozone-induced bronchial hyperreactivity. Am Rev Respir Dis. 1985 Mar;131(3):314–320. doi: 10.1164/arrd.1985.131.3.314. [DOI] [PubMed] [Google Scholar]
  50. O'Byrne P. M., Walters E. H., Aizawa H., Fabbri L. M., Holtzman M. J., Nadel J. A. Indomethacin inhibits the airway hyperresponsiveness but not the neutrophil influx induced by ozone in dogs. Am Rev Respir Dis. 1984 Aug;130(2):220–224. doi: 10.1164/arrd.1984.130.2.220. [DOI] [PubMed] [Google Scholar]
  51. O'Byrne P. M., Walters E. H., Gold B. D., Aizawa H. A., Fabbri L. M., Alpert S. E., Nadel J. A., Holtzman M. J. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis. 1984 Aug;130(2):214–219. doi: 10.1164/arrd.1984.130.2.214. [DOI] [PubMed] [Google Scholar]
  52. O'Donnell M. C., Ackerman S. J., Gleich G. J., Thomas L. L. Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med. 1983 Jun 1;157(6):1981–1991. doi: 10.1084/jem.157.6.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Persson C. G., Svensjö E. Airway hyperreactivity and microvascular permeability to large molecules. Eur J Respir Dis Suppl. 1983;131:183–214. [PubMed] [Google Scholar]
  54. Platts-Mills T. A., Tovey E. R., Mitchell E. B., Moszoro H., Nock P., Wilkins S. R. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet. 1982 Sep 25;2(8300):675–678. doi: 10.1016/s0140-6736(82)90709-7. [DOI] [PubMed] [Google Scholar]
  55. Robinson C., Holgate S. T. Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. Clin Sci (Lond) 1985 Feb;68(2):103–112. doi: 10.1042/cs0680103. [DOI] [PubMed] [Google Scholar]
  56. Roum J. H., Murlas C. Ozone-induced changes in muscarinic bronchial reactivity by different testing methods. J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1783–1789. doi: 10.1152/jappl.1984.57.6.1783. [DOI] [PubMed] [Google Scholar]
  57. Seltzer J., Bigby B. G., Stulbarg M., Holtzman M. J., Nadel J. A., Ueki I. F., Leikauf G. D., Goetzl E. J., Boushey H. A. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol (1985) 1986 Apr;60(4):1321–1326. doi: 10.1152/jappl.1986.60.4.1321. [DOI] [PubMed] [Google Scholar]
  58. Solley G. O., Gleich G. J., Jordon R. E., Schroeter A. L. The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies. J Clin Invest. 1976 Aug;58(2):408–420. doi: 10.1172/JCI108485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Tomioka M., Ida S., Shindoh Y., Ishihara T., Takishima T. Mast cells in bronchoalveolar lumen of patients with bronchial asthma. Am Rev Respir Dis. 1984 Jun;129(6):1000–1005. doi: 10.1164/arrd.1984.129.6.1000. [DOI] [PubMed] [Google Scholar]
  60. Vincenc K. S., Black J. L., Yan K., Armour C. L., Donnelly P. D., Woolcock A. J. Comparison of in vivo and in vitro responses to histamine in human airways. Am Rev Respir Dis. 1983 Nov;128(5):875–879. doi: 10.1164/arrd.1983.128.5.875. [DOI] [PubMed] [Google Scholar]
  61. Walters E. H., Parrish R. W., Bevan C., Smith A. P. Induction of bronchial hypersensitivity: evidence for a role for prostaglandins. Thorax. 1981 Aug;36(8):571–574. doi: 10.1136/thx.36.8.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Weller P. F., Lee C. W., Foster D. W., Corey E. J., Austen K. F., Lewis R. A. Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc Natl Acad Sci U S A. 1983 Dec;80(24):7626–7630. doi: 10.1073/pnas.80.24.7626. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES