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. 1977 Dec;32(6):752–758. doi: 10.1136/thx.32.6.752

Primary mediastinal trophoblastic teratomas.

P A Walden, R L Woods, B Fox, K D Bagshawe
PMCID: PMC470827  PMID: 74864

Abstract

Three cases of primary mediastinal trophoblastic teratoma are described. One patient died from respiratory failure during the initial chemotherapy, Another patient with advanced disease is now apparently free from disease after multiple-drug chemotherapy. The third patient is alive and well four years after a combination of surgery, radiotherapy, and multiple-drug chemotherapy. In the diagnosis and assessment of response to treatment in these tumours emphasis is placed on the measurement of the tumour cell markers, chorionic gonadotrophin and alpha-fetoprotein, by radioimmunoassay. The efficacy of multiple-drug regimens is discussed together with a review of the literature.

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Selected References

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  1. AZZOPARDI J. G., MOSTOFI F. K., THEISS E. A. Lesions of testes observed in certain patients with widespread choriocarcinoma and related tumors. The significance and genesis of hematoxylin-staining bodies in the human testis. Am J Pathol. 1961 Feb;38:207–225. [PMC free article] [PubMed] [Google Scholar]
  2. Asif S., Uehling D. T. Microscopic tumor foci in testes. J Urol. 1968 Jun;99(6):776–779. doi: 10.1016/S0022-5347(17)62792-7. [DOI] [PubMed] [Google Scholar]
  3. BENNINGTON J. L., HABER S. L., SCHWEID A. PRIMARY MEDIASTINAL CHORIOCARCINOMA. REPORT OF A CASE. Dis Chest. 1964 Nov;46:623–626. doi: 10.1378/chest.46.5.623. [DOI] [PubMed] [Google Scholar]
  4. Belliveau R. E., Wiernik P. H., Sickles E. A. Blood carcinoembryonic antigen, Regan isoenzyme, and human chorionic gonadotrophin in a man with primary mediastinal choriocarcinoma. Lancet. 1973 Jan 6;1(7793):22–24. doi: 10.1016/s0140-6736(73)91227-0. [DOI] [PubMed] [Google Scholar]
  5. Das P. B., Bhaktaviziam A., Gupta R. P., Kanhere M. H., Jairaj P. S., Ray D., John S. Primary malignant tumours of the mediastinum and their management. Aust N Z J Surg. 1975 Feb;45(1):42–48. doi: 10.1111/j.1445-2197.1975.tb05721.x. [DOI] [PubMed] [Google Scholar]
  6. FINE G., SMITH R. W., Jr, PACHTER M. R. Primary extragenital choriocarcinoma in the male subject. Case report and review of the literature. Am J Med. 1962 May;32:776–794. doi: 10.1016/0002-9343(62)90167-5. [DOI] [PubMed] [Google Scholar]
  7. Goldstein D. P., Piro A. J. Combination chemotherapy in the treatment of germ cell tumors containing choriocarcinoma in males and females. Surg Gynecol Obstet. 1972 Jan;134(1):61–66. [PubMed] [Google Scholar]
  8. Greenwood S. M., Forman B. H., Goodman J. R., Kress S. C., Schneider G., Gelb A. F. Choriocarcinoma in a man. The relationship of gynecomastia to chorionic somatomammotropin and estrogens. Am J Med. 1971 Sep;51(3):416–422. doi: 10.1016/0002-9343(71)90278-6. [DOI] [PubMed] [Google Scholar]
  9. Johnson D. E., Laneri J. P., Mountain C. F., Luna M. Extragonadal germ cell tumors. Surgery. 1973 Jan;73(1):85–90. [PubMed] [Google Scholar]
  10. Kantrowitz A. R. Extragenital Chorionepithelioma in a Male. Am J Pathol. 1934 Jul;10(4):531–544.3. [PMC free article] [PubMed] [Google Scholar]
  11. Katzenstein A. L., Bloor C. M., Leibow A. A. Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review. Am J Pathol. 1976 Oct;85(1):209–228. [PMC free article] [PubMed] [Google Scholar]
  12. LI M. C., WHITMORE W. F., Jr, GOLBEY R., GRABSTALD H. Effects of combined drug therapy on metastatic cancer of the testis. JAMA. 1960 Nov 5;174:1291–1299. doi: 10.1001/jama.1960.03030100059013. [DOI] [PubMed] [Google Scholar]
  13. LYNCH M. J., BLEWITT G. L. Choriocarcinoma arising in the male mediastinum. Thorax. 1953 Jun;8(2):157–161. doi: 10.1136/thx.8.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MAGOVERN G. J., BLADES B. Primary extragenital chorioepithelioma in the male mediastinum. J Thorac Surg. 1958 Mar;35(3):378–383. [PubMed] [Google Scholar]
  15. Martini N., Golbey R. B., Hajdu S. I., Whitmore W. F., Beattie E. J., Jr Primary mediastinal germ cell tumors. Cancer. 1974 Mar;33(3):763–769. doi: 10.1002/1097-0142(197403)33:3<763::aid-cncr2820330323>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  16. PACHTER M. R., LATTES R. "GERMINAL" TUMORS OF THE MEDIASTINUM: A CLINICOPATHOLOGIC STUDY OF ADULT TERATOMAS, TERATOCARCINOMAS, CHORIOCARCINOMAS AND SEMINOMAS. Dis Chest. 1964 Mar;45:301–310. doi: 10.1378/chest.45.3.301. [DOI] [PubMed] [Google Scholar]
  17. Peison B. Embryonal teratocarcinoma of the mediastinum in a woman with foci of anaplastic cells simulating chorioepithelioma. Chest. 1970 Aug;58(2):169–172. doi: 10.1378/chest.58.2.169. [DOI] [PubMed] [Google Scholar]
  18. RATHER L. J., GARDINER W. R., FRERICHS J. B. Regression and maturation of primary testicular tumors with progressive growth of metastases; a report of six new cases and a review of the literature. Stanford Med Bull. 1954 Feb;12(1):12–25. [PubMed] [Google Scholar]
  19. Rosenow E. C., 3rd The spectrum of drug-induced pulmonary disease. Ann Intern Med. 1972 Dec;77(6):977–991. doi: 10.7326/0003-4819-77-6-977. [DOI] [PubMed] [Google Scholar]
  20. SCHAFER H. Extragenitlaes Chorionepitheliom bei einem Mann. Strahlentherapie. 1959 Feb;108(2):283–287. [PubMed] [Google Scholar]
  21. Safer M. L., Green J. P., Crews Q. E., Hill D. R. Lymphangigraphic accuracy in the staging of testicular tumors. Cancer. 1975 Jun;35(6):1603–1605. doi: 10.1002/1097-0142(197506)35:6<1603::aid-cncr2820350619>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  22. Sickles E. A., Belliveau R. E., Wiernik P. H. Primary mediastinal choriocarcinoma in the male. Cancer. 1974 Apr;33(4):1196–1203. doi: 10.1002/1097-0142(197404)33:4<1196::aid-cncr2820330445>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  23. Utz D. C., Buscemi M. F. Extragonadal testicular tumors. J Urol. 1971 Feb;105(2):271–274. doi: 10.1016/s0022-5347(17)61508-8. [DOI] [PubMed] [Google Scholar]
  24. Wacksman J., Case G., Glenn J. F. Extragenital gonadal neoplasia and metastatic testicular tumor. Urology. 1975 Feb;5(2):221–223. doi: 10.1016/0090-4295(75)90014-x. [DOI] [PubMed] [Google Scholar]
  25. Wenger M. E., Dines D. E., Ahmann D. L., Good C. A. Primary mediastinal choriocarcinoma. Mayo Clin Proc. 1968 Aug;43(8):570–575. [PubMed] [Google Scholar]
  26. Wilkinson D. J., MacDonald J. S. A review of the role of lymphography in the management of testicular tumours. Clin Radiol. 1975 Jan;26(1):89–98. doi: 10.1016/s0009-9260(75)80020-1. [DOI] [PubMed] [Google Scholar]
  27. YURICK B. S., OTTOMAN R. E. Primary mediastinal choriocarcinoma. Radiology. 1960 Dec;75:901–907. doi: 10.1148/75.6.901. [DOI] [PubMed] [Google Scholar]

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