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. 1982 Oct;48(4):352–356. doi: 10.1136/hrt.48.4.352

Serum levels of acute phase and cardiac proteins after myocardial infarction, surgery, and infection.

F Voulgari, P Cummins, T I Gardecki, N J Beeching, P C Stone, J Stuart
PMCID: PMC481259  PMID: 6181800

Abstract

C-reactive protein and four other acute phase reactant proteins of non-cardiac, origin (orosomucoid, alpha 1- antitrypsin, heptoglobin, and alpha 2- macroglobulin) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction. A similar comparison was made in 57 patients undergoing surgery and 72 patients with acute infection. C-reactive protein was consistently the most sensitive acute phase reactant in all three conditions. After myocardial infarction, a raised serum C-reactive protein level was found on admission in four patients before a rise in creatine kinase MB isoenzyme (CK MB). The peak C-reactive protein level was reached on the third post-infarct day and it then declined over seven days with a half-life similar to myocardial tropomyosin. Serial monitoring of serum C-reactive protein, in parallel with cardiac proteins of short half-life (CK MB) and long half-life (tropomyosin), provides maximal information for diagnosis and for detecting post-infarct complications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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