Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1982 Oct;48(4):352–356. doi: 10.1136/hrt.48.4.352

Serum levels of acute phase and cardiac proteins after myocardial infarction, surgery, and infection.

F Voulgari, P Cummins, T I Gardecki, N J Beeching, P C Stone, J Stuart
PMCID: PMC481259  PMID: 6181800

Abstract

C-reactive protein and four other acute phase reactant proteins of non-cardiac, origin (orosomucoid, alpha 1- antitrypsin, heptoglobin, and alpha 2- macroglobulin) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction. A similar comparison was made in 57 patients undergoing surgery and 72 patients with acute infection. C-reactive protein was consistently the most sensitive acute phase reactant in all three conditions. After myocardial infarction, a raised serum C-reactive protein level was found on admission in four patients before a rise in creatine kinase MB isoenzyme (CK MB). The peak C-reactive protein level was reached on the third post-infarct day and it then declined over seven days with a half-life similar to myocardial tropomyosin. Serial monitoring of serum C-reactive protein, in parallel with cardiac proteins of short half-life (CK MB) and long half-life (tropomyosin), provides maximal information for diagnosis and for detecting post-infarct complications.

Full text

PDF
354

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crockson R. A., Payne C. J., Ratcliff A. P., Soothill J. F. Time sequence of acute phase reactive proteins following surgical trauma. Clin Chim Acta. 1966 Oct;14(4):435–441. doi: 10.1016/0009-8981(66)90030-1. [DOI] [PubMed] [Google Scholar]
  2. Cummins P., McGurk B., Littler W. A. Radioimmunoassay of human cardiac tropomyosin in acute myocardial infarction. Clin Sci (Lond) 1981 Mar;60(3):251–259. doi: 10.1042/cs0600251. [DOI] [PubMed] [Google Scholar]
  3. ELSTER S. K., LEVINGER E. L., LEVY H. Study of C-reactive protein in the sera of patients with acute myocardial infarction. Ann Intern Med. 1957 Jan;46(1):68–78. doi: 10.7326/0003-4819-46-1-68. [DOI] [PubMed] [Google Scholar]
  4. GUREVIN I., KOZONIS M. C. The value of the C-reactive protein determination in coronary artery disease. Ann Intern Med. 1957 Jan;46(1):79–85. doi: 10.7326/0003-4819-46-1-79. [DOI] [PubMed] [Google Scholar]
  5. HEDLUND P. Clinical and experimental studies on C-reactive protein (acute phase protein). Acta Med Scand Suppl. 1961;361:1–71. [PubMed] [Google Scholar]
  6. Johansson B. G., Kindmark C. O., Trell E. Y., Wollheim F. A. Sequential changes of plasma proteins after myocardial infarction. Scand J Clin Lab Invest Suppl. 1972;124:117–126. doi: 10.3109/00365517209102759. [DOI] [PubMed] [Google Scholar]
  7. KROOP I. G., SHACKMAN N. H. The C-reactive protein determination as an index of myocardial necrosis in coronary artery disease. Am J Med. 1957 Jan;22(1):90–98. doi: 10.1016/0002-9343(57)90340-6. [DOI] [PubMed] [Google Scholar]
  8. Kenny M. W., Worthington D. J., Stuart J., Davies A. J., Farr M., Davey P. G., Chughtai M. A. Efficiency of haematological screening tests for detecting disease. Clin Lab Haematol. 1981;3(4):299–305. [PubMed] [Google Scholar]
  9. Kushner I., Broder M. L., Karp D. Control of the acute phase response. Serum C-reactive protein kinetics after acute myocardial infarction. J Clin Invest. 1978 Feb;61(2):235–242. doi: 10.1172/JCI108932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pepys M. B. C-reactive protein fifty years on. Lancet. 1981 Mar 21;1(8221):653–657. doi: 10.1016/s0140-6736(81)91565-8. [DOI] [PubMed] [Google Scholar]
  11. ROANTREE R. J., RANTZ L. A. Clinical experience with the C-reactive protein test. AMA Arch Intern Med. 1955 Nov;96(5):674–682. doi: 10.1001/archinte.1955.00250160116009. [DOI] [PubMed] [Google Scholar]
  12. Rose P. E., Johnsdon S. A., Meakin M., Mackie P. H., Stuart J. Serial study of C-reactive protein during infection in leukaemia. J Clin Pathol. 1981 Mar;34(3):263–266. doi: 10.1136/jcp.34.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Surtees S. J., Bastable M. D., Gietzen T. W., Model D. G., Carmichael D. J., Bordoli G., Kidner P. H. A biochemical and clinical comparison of two commercially available creatine kinase iso-enzyme MB assay kits suitable for use in the routine medical laboratory. Ann Clin Biochem. 1979 Jul;16(4):197–204. doi: 10.1177/000456327901600147. [DOI] [PubMed] [Google Scholar]
  14. Trahern C. A., Gere J. B., Krauth G. H., Bigham D. A. Clinical assessment of serum myosin light chains in the diagnosis of acute myocardial infarction. Am J Cardiol. 1978 Apr;41(4):641–645. doi: 10.1016/0002-9149(78)90811-1. [DOI] [PubMed] [Google Scholar]
  15. de Beer F. C., Hind C. R., Fox K. M., Allan R. M., Maseri A., Pepys M. B. Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br Heart J. 1982 Mar;47(3):239–243. doi: 10.1136/hrt.47.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES