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. 1998 Mar;51(3):207–210. doi: 10.1136/jcp.51.3.207

Lymphocytic gastritis and coeliac disease: evidence of a positive association.

K M Feeley 1, M A Heneghan 1, F M Stevens 1, C F McCarthy 1
PMCID: PMC500640  PMID: 9659261

Abstract

AIMS: To investigate the prevalence of lymphocytic gastritis in patients with coeliac disease. METHODS: Gastric biopsies from 70 patients with coeliac disease were examined by light microscopy for the presence of lymphocytic gastritis, defined as 25 or more intraepithelial lymphocytes/100 gastric columnar epithelial cells. RESULTS: Lymphocytic gastritis was found in seven cases. Positive cases had a mean of 32.1 intraepithelial lymphocytes/100 columnar cells, compared with a mean of 13.9 in negative cases, and 5.15 in noncoeliac controls. No differences were found for age, sex, gastric corpus or antrum, or degree of inflammation in the gastric lamina propria. All intraepithelial lymphocytes were of T cell lineage. Cases not showing lymphocytic gastritis did however show significantly increased gastric intraepithelial lymphocytes compared with non-coeliac controls. Eighteen of 70 cases were positive for Helicobacter pylori, and four of seven cases of lymphocytic gastritis were H pylori positive; no significant difference was observed between H pylori positive and negative patients. Three cases had concomitant ulcerative enteritis, of which none showed lymphocytic gastritis, while five cases had concomitant enteropathy associated T cell lymphoma, of which one showed lymphocytic gastritis. CONCLUSIONS: Lymphocytic gastritis occurred in 10% of patients with coeliac disease. Cases without lymphocytic gastritis nevertheless showed increased gastric intraepithelial lymphocytes. Coeliac disease may on occasion be a diffuse lymphocytic enteropathy occurring in response to gluten. Lymphocytic gastritis outside coeliac disease may involve an immune response to luminal antigens, such as H pylori, not unlike the response to gluten in patients with coeliac disease.

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Selected References

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  1. Alsaigh N., Odze R., Goldman H., Antonioli D., Ott M. J., Leichtner A. Gastric and esophageal intraepithelial lymphocytes in pediatric celiac disease. Am J Surg Pathol. 1996 Jul;20(7):865–870. doi: 10.1097/00000478-199607000-00010. [DOI] [PubMed] [Google Scholar]
  2. De Giacomo C., Gianatti A., Negrini R., Perotti P., Bawa P., Maggiore G., Fiocca R. Lymphocytic gastritis: a positive relationship with celiac disease. J Pediatr. 1994 Jan;124(1):57–62. doi: 10.1016/s0022-3476(94)70254-3. [DOI] [PubMed] [Google Scholar]
  3. Dixon M. F., Wyatt J. I., Burke D. A., Rathbone B. J. Lymphocytic gastritis--relationship to Campylobacter pylori infection. J Pathol. 1988 Feb;154(2):125–132. doi: 10.1002/path.1711540204. [DOI] [PubMed] [Google Scholar]
  4. Farahat K., Hainaut P., Jamar F., Haot J., Lambert M. Lymphocytic gastritis: an unusual cause of hypoproteinaemia. J Intern Med. 1993 Jul;234(1):95–100. doi: 10.1111/j.1365-2796.1993.tb00711.x. [DOI] [PubMed] [Google Scholar]
  5. Griffiths A. P., Wyatt J., Jack A. S., Dixon M. F. Lymphocytic gastritis, gastric adenocarcinoma, and primary gastric lymphoma. J Clin Pathol. 1994 Dec;47(12):1123–1124. doi: 10.1136/jcp.47.12.1123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Haot J., Hamichi L., Wallez L., Mainguet P. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study. Gut. 1988 Sep;29(9):1258–1264. doi: 10.1136/gut.29.9.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haot J., Jouret A., Willette M., Gossuin A., Mainguet P. Lymphocytic gastritis--prospective study of its relationship with varioliform gastritis. Gut. 1990 Mar;31(3):282–285. doi: 10.1136/gut.31.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Karttunen T., Niemelä S. Lymphocytic gastritis and coeliac disease. J Clin Pathol. 1990 May;43(5):436–437. doi: 10.1136/jcp.43.5.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Miettinen A., Karttunen T. J., Alavaikko M. Lymphocytic gastritis and Helicobacter pylori infection in gastric lymphoma. Gut. 1995 Oct;37(4):471–476. doi: 10.1136/gut.37.4.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mylotte M., Egan-Mitchell B., McCarthy C. F., McNicholl B. Incidence of coeliac disease in the West of Ireland. Br Med J. 1973 Mar 24;1(5855):703–705. doi: 10.1136/bmj.1.5855.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Niemelä S., Karttunen T., Kerola T., Karttunen R. Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. J Clin Pathol. 1995 Dec;48(12):1111–1116. doi: 10.1136/jcp.48.12.1111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wolber R. A., Owen D. A., Anderson F. H., Freeman H. J. Lymphocytic gastritis and giant gastric folds associated with gastrointestinal protein loss. Mod Pathol. 1991 Jan;4(1):13–15. [PubMed] [Google Scholar]
  13. Wolber R., Owen D., DelBuono L., Appelman H., Freeman H. Lymphocytic gastritis in patients with celiac sprue or spruelike intestinal disease. Gastroenterology. 1990 Feb;98(2):310–315. doi: 10.1016/0016-5085(90)90819-m. [DOI] [PubMed] [Google Scholar]
  14. Wolfsen H. C., Carpenter H. A., Talley N. J. Menetrier's disease: a form of hypertrophic gastropathy or gastritis? Gastroenterology. 1993 May;104(5):1310–1319. doi: 10.1016/0016-5085(93)90339-e. [DOI] [PubMed] [Google Scholar]
  15. Zhong F., McCombs C. C., Olson J. M., Elston R. C., Stevens F. M., McCarthy C. F., Michalski J. P. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nat Genet. 1996 Nov;14(3):329–333. doi: 10.1038/ng1196-329. [DOI] [PubMed] [Google Scholar]

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