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. 1992 Sep;76(9):571–573. doi: 10.1136/bjo.76.9.571

Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy.

F X Borruat 1, W T Green 1, E M Graham 1, M G Sweeney 1, J A Morgan-Hughes 1, M D Sanders 1
PMCID: PMC504353  PMID: 1420066

Abstract

A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778.

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Selected References

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