Abstract
A retrospective analysis has been performed of the results of external beam radiotherapy for retinoblastoma using a whole eye technique. Local tumour control has been assessed in a consecutive series of 175 eyes in 142 children all of whom received external beam radiotherapy as the primary treatment for retinoblastoma. Follow up ranged from 2 to 17 years (median 9 years). Tumour control rates have been analysed with respect to the Reese Ellsworth classification and the series includes eyes in groups I to V. Focal salvage therapy was given for persistent, recurrent, or new tumours after radiotherapy. Following whole eye radiotherapy alone, the overall ocular cure rate was 57%, though with salvage therapy 80% of eyes could be preserved.
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- Bedford M. A., Bedotto C., Macfaul P. A. Retinoblastoma. A study of 139 cases. Br J Ophthalmol. 1971 Jan;55(1):19–27. doi: 10.1136/bjo.55.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Egbert P. R., Donaldson S. S., Moazed K., Rosenthal A. R. Visual results and ocular complications following radiotherapy for retinoblastoma. Arch Ophthalmol. 1978 Oct;96(10):1826–1830. doi: 10.1001/archopht.1978.03910060338008. [DOI] [PubMed] [Google Scholar]
- Ellsworth R. M. Retinoblastoma. Mod Probl Ophthalmol. 1977;18:94–100. [PubMed] [Google Scholar]
- Foote R. L., Garretson B. R., Schomberg P. J., Buskirk S. J., Robertson D. M., Earle J. D. External beam irradiation for retinoblastoma: patterns of failure and dose-response analysis. Int J Radiat Oncol Biol Phys. 1989 Mar;16(3):823–830. doi: 10.1016/0360-3016(89)90502-6. [DOI] [PubMed] [Google Scholar]
- Freeman C. R., Esseltine D. L., Whitehead V. M., Chevalier L., Little J. M. Retinoblastoma: the case for radiotherapy and for adjuvant chemotherapy. Cancer. 1980 Nov 1;46(9):1913–1918. doi: 10.1002/1097-0142(19801101)46:9<1913::aid-cncr2820460904>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Harnett A. N., Hungerford J. L., Lambert G. D., Hirst A., Darlison R., Hart B. L., Trodd T. C., Plowman P. N. Improved external beam radiotherapy for the treatment of retinoblastoma. Br J Radiol. 1987 Aug;60(716):753–760. doi: 10.1259/0007-1285-60-716-753. [DOI] [PubMed] [Google Scholar]
- Howarth C., Meyer D., Hustu H. O., Johnson W. W., Shanks E., Pratt C. Stage-related combined modality treatment of retinoblastoma. Results of a prospective study. Cancer. 1980 Mar 1;45(5):851–858. doi: 10.1002/1097-0142(19800301)45:5<851::aid-cncr2820450505>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- Macfaul P. A., Bedford M. A. Ocular complications after therapeutic irradiation. Br J Ophthalmol. 1970 Apr;54(4):237–247. doi: 10.1136/bjo.54.4.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Migdal C. Bilateral retinoblastoma: the prognosis for vision. Br J Ophthalmol. 1983 Sep;67(9):592–595. doi: 10.1136/bjo.67.9.592. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REESE A. B., ELLSWORTH R. M. The evaluation and current concept of retinoblastoma therapy. Trans Am Acad Ophthalmol Otolaryngol. 1963 Mar-Apr;67:164–172. [PubMed] [Google Scholar]
- Sanders B. M., Draper G. J., Kingston J. E. Retinoblastoma in Great Britain 1969-80: incidence, treatment, and survival. Br J Ophthalmol. 1988 Aug;72(8):576–583. doi: 10.1136/bjo.72.8.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schipper J. An accurate and simple method for megavoltage radiation therapy of retinoblastoma. Radiother Oncol. 1983 Aug;1(1):31–41. doi: 10.1016/s0167-8140(83)80005-x. [DOI] [PubMed] [Google Scholar]
- Schipper J., Tan K. E., van Peperzeel H. A. Treatment of retinoblastoma by precision megavoltage radiation therapy. Radiother Oncol. 1985 Feb;3(2):117–132. doi: 10.1016/s0167-8140(85)80016-5. [DOI] [PubMed] [Google Scholar]
- Skeggs D. B., Williams I. G. The treatment of advanced retinoblastoma by means of external irradiation combined with chemotherapy. Clin Radiol. 1966 Apr;17(2):169–172. doi: 10.1016/s0009-9260(66)80081-8. [DOI] [PubMed] [Google Scholar]
- Toma N. M., Hungerford J. L., Plowman P. N., Kingston J. E., Doughty D. External beam radiotherapy for retinoblastoma: II. Lens sparing technique. Br J Ophthalmol. 1995 Feb;79(2):112–117. doi: 10.1136/bjo.79.2.112. [DOI] [PMC free article] [PubMed] [Google Scholar]