Abstract
The product of phage P22 gene c1 has two functions: it promotes synthesis of P22 repressor and it retards expression of some lytic genes. We present evidence that this product is inactivated in UV-irradiated hosts. The conditions for inactivation of c1 product include a functional DNA recombination system involving the host recA gene.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Botstein D., Herskowitz I. Properties of hybrids between Salmonella phage P22 and coliphage lambda. Nature. 1974 Oct 18;251(5476):584–589. doi: 10.1038/251584a0. [DOI] [PubMed] [Google Scholar]
- Bronson M. J., Levine M. Virulent mutants of phage P22. II. Physiological analysis of P22 virB-3 and its component mutations. Virology. 1972 Mar;47(3):644–655. doi: 10.1016/0042-6822(72)90554-5. [DOI] [PubMed] [Google Scholar]
- Court D., Green L., Echols H. Positive and negative regulation by the cII and cIII gene products of bacteriophage lambda. Virology. 1975 Feb;63(2):484–491. doi: 10.1016/0042-6822(75)90321-9. [DOI] [PubMed] [Google Scholar]
- Echols H. Developmental pathways for the temperate phage: lysis vs lysogeny,. Annu Rev Genet. 1972;6(0):157–190. doi: 10.1146/annurev.ge.06.120172.001105. [DOI] [PubMed] [Google Scholar]
- FRY B. A. Conditions for the infection of Escherichia coli with lambda phage and for the establishment of lysogeny. J Gen Microbiol. 1959 Dec;21:676–684. doi: 10.1099/00221287-21-3-676. [DOI] [PubMed] [Google Scholar]
- Gough M., Tokuno S. Further structural and functional analogies between the repressor regions of phages P22 and lambda. Mol Gen Genet. 1975;138(1):71–79. doi: 10.1007/BF00268829. [DOI] [PubMed] [Google Scholar]
- Hong J. S., Smith G. R., Ames B. N. Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2258–2262. doi: 10.1073/pnas.68.9.2258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEVINE M. Mutations in the temperate phage P22 and lysogeny in Salmonella. Virology. 1957 Feb;3(1):22–41. doi: 10.1016/0042-6822(57)90021-1. [DOI] [PubMed] [Google Scholar]
- LIEB M. The establishment of lysogenicity in Escherichia coli. J Bacteriol. 1953 Jun;65(6):642–651. doi: 10.1128/jb.65.6.642-651.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levine M., Schott C. Mutations of phage P22 affecting phage DNA synthesis and lysogenization. J Mol Biol. 1971 Nov 28;62(1):53–64. doi: 10.1016/0022-2836(71)90130-6. [DOI] [PubMed] [Google Scholar]
- Roberts J. W., Roberts C. W. Proteolytic cleavage of bacteriophage lambda repressor in induction. Proc Natl Acad Sci U S A. 1975 Jan;72(1):147–151. doi: 10.1073/pnas.72.1.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH H. O., LEVINE M. TWO SEQUENTIAL REPRESSIONS OF DNA SYNTHESIS IN THE ESTABLISHMENT OF LYSOGENY BY PHAGE P22 AND ITS MUTANTS. Proc Natl Acad Sci U S A. 1964 Aug;52:356–363. doi: 10.1073/pnas.52.2.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shinagawa H., Ito T. Inactivation of DNA-binding activity of repressor in extracts of lambda-lysogen treated with mitomycin C. Mol Gen Genet. 1973 Nov 2;126(2):103–110. doi: 10.1007/BF00330987. [DOI] [PubMed] [Google Scholar]
- Steinberg B., Gough M. Altered DNA synthesis in a mutant of Salmonella typhimurium that channels bacteriophage P22 toward lysogeny. J Virol. 1975 Nov;16(5):1154–1160. doi: 10.1128/jvi.16.5.1154-1160.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steinberg R. A., Ptashne M. In vitro repression of RNA synthesis by purified lambda phage repressor. Nat New Biol. 1971 Mar 17;230(11):76–80. doi: 10.1038/newbio230076a0. [DOI] [PubMed] [Google Scholar]
- Sussman R., Zeev H. B. Proposed mechanism of bacteriophage lambda induction: acquisition of binding sites for lambda repressor by DNA of the host. Proc Natl Acad Sci U S A. 1975 May;72(5):1973–1976. doi: 10.1073/pnas.72.5.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tokuno S. I., Goldschmidt E. P., Gough M. Mutant of Salmonella typhimurium that channels infecting bacteriophage P22 toward lysogenization. J Bacteriol. 1974 Aug;119(2):508–513. doi: 10.1128/jb.119.2.508-513.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tokuno S. I., Gough M. Host influence on the activity of genes c1 and c3 in regulating the decision between lysis and lysogency in bacteriophage P22. J Virol. 1975 Nov;16(5):1184–1190. doi: 10.1128/jvi.16.5.1184-1190.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tomizawa J., Ogawa T. Effect of ultraviolet irradiation on bacteriophage lambda immunity. J Mol Biol. 1967 Jan 28;23(2):247–263. doi: 10.1016/s0022-2836(67)80031-7. [DOI] [PubMed] [Google Scholar]
- Wing J. P. Integration and induction of phage P22 in a recombination-deficient mutant of Salmonella typhimurium. J Virol. 1968 Jul;2(7):702–709. doi: 10.1128/jvi.2.7.702-709.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]