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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1983 Oct;80(19):6136–6140. doi: 10.1073/pnas.80.19.6136

Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.

S S Schiffman, E Lockhead, F W Maes
PMCID: PMC534376  PMID: 6577473

Abstract

The diuretic amiloride, a potent inhibitor of sodium transport in a variety of epithelial systems, was applied to the human tongue. Application of amiloride reduced the taste intensity of sodium and lithium salts and of sweeteners ranging widely in chemical structure. The sweeteners included saccharides, glycosides, dipeptides, proteins, and amino acids. Amiloride did not affect perception of potassium or calcium salts, bitter and sour tastes, or amino acids without a sweet or salty component. These findings were supported by neurophysiological studies in rat, which showed that amiloride diminished the NaCl response relative to KCl. The results are consistent with the position that an amiloride-sensitive transport mechanism is involved in taste perception of sodium and lithium salts and of sweeteners.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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