Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1987 Feb;40(2):232–236. doi: 10.1136/jcp.40.2.232

Diversity of autoantibodies in patients with antimitochondrial antibody and their diagnostic value.

S A McMillan, J M Alderdice, C M McKee, A T Dawson, M E Callender, T T Fulton, M Haire
PMCID: PMC1140874  PMID: 3546398

Abstract

A retrospective analysis of clinical and laboratory features of 102 patients, whose sera contained antibody to mitochondria, showed that primary biliary cirrhosis was diagnosed in 50% of them. Immunofluorescence showed that the sera of the patients with primary biliary cirrhosis all had the M2 antimitochondrial antibody staining pattern. A new staining pattern, designated M2(1), which could be mistaken for the M2 pattern, was not found in any patients with either primary biliary cirrhosis or chronic active hepatitis. Other serological variables such as antibody to mitochondria in IgM class, to multiple nuclear dots, and to the XR antigen, were associated with primary biliary cirrhosis, and taken in association with antimitochondrial antibody of M2 type, contribute to the diagnosis of the disease.

Full text

PDF
234

Images in this article

234Fig 1
on p.234
234Fig 2
on p.234
234Fig 3
on p.234

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akizuki M., Boehm-Truitt M. J., Kassan S. S., Steinberg A. D., Chused T. M. Purification of an acidic nuclear protein antigen and demonstration of its antibodies in subsets of patients with sicca syndrome. J Immunol. 1977 Sep;119(3):932–938. [PubMed] [Google Scholar]
  2. Alspaugh M. A., Tan E. M. Antibodies to cellular antigens in Sjögren's syndrome. J Clin Invest. 1975 May;55(5):1067–1073. doi: 10.1172/JCI108007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baum H., Berg P. A. The complex nature of mitochondrial antibodies and their relation to primary biliary cirrhosis. Semin Liver Dis. 1981 Nov;1(4):309–321. doi: 10.1055/s-2008-1040734. [DOI] [PubMed] [Google Scholar]
  4. Baum H., Berg P. A. The complex nature of mitochondrial antibodies and their relation to primary biliary cirrhosis. Semin Liver Dis. 1981 Nov;1(4):309–321. doi: 10.1055/s-2008-1040734. [DOI] [PubMed] [Google Scholar]
  5. Berg P. A., Homberg J. C., Bottazzo G. F., Doniach D. Clinical significance of mitochondrial antibodies in relation to liver disease. Lancet. 1981 Oct 10;2(8250):804–804. doi: 10.1016/s0140-6736(81)90206-3. [DOI] [PubMed] [Google Scholar]
  6. Berg P. A., Klein R. Clinical and prognostic relevance of different mitochondrial antibody profiles in primary biliary cirrhosis (PBC). Mol Aspects Med. 1985;8(3):235–247. doi: 10.1016/0098-2997(85)90008-1. [DOI] [PubMed] [Google Scholar]
  7. Bernstein R. M., Callender M. E., Neuberger J. M., Hughes G. R., Williams R. Anticentromere antibody in primary biliary cirrhosis. Ann Rheum Dis. 1982 Dec;41(6):612–614. doi: 10.1136/ard.41.6.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bernstein R. M., Neuberger J. M., Bunn C. C., Callender M. E., Hughes G. R., Williams R. Diversity of autoantibodies in primary biliary cirrhosis and chronic active hepatitis. Clin Exp Immunol. 1984 Mar;55(3):553–560. [PMC free article] [PubMed] [Google Scholar]
  9. Bunn C. C., Gharavi A. E., Hughes G. R. Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis. J Clin Lab Immunol. 1982 May;8(1):13–17. [PubMed] [Google Scholar]
  10. Doniach D., Roitt I. M., Walker J. G., Sherlock S. Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications. Clin Exp Immunol. 1966 Jul;1(3):237–262. [PMC free article] [PubMed] [Google Scholar]
  11. Klatskin G., Kantor F. S. Mitochondrial antibody in primary biliary cirrhosis and other diseases. Ann Intern Med. 1972 Oct;77(4):533–541. doi: 10.7326/0003-4819-77-4-533. [DOI] [PubMed] [Google Scholar]
  12. Labro M. T., Andrieu M. C., Weber M., Homberg J. C. A new pattern of non-organ- and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5. Clin Exp Immunol. 1978 Mar;31(3):357–366. [PMC free article] [PubMed] [Google Scholar]
  13. Munoz L. E., Thomas H. C., Scheuer P. J., Doniach D., Sherlock S. Is mitochondrial antibody diagnostic of primary biliary cirrhosis? Gut. 1981 Feb;22(2):136–140. doi: 10.1136/gut.22.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Powell F., Schroeter A. L., Dickson E. R. Antinuclear antibodies in primary biliary cirrhosis. Lancet. 1984 Feb 4;1(8371):288–289. doi: 10.1016/s0140-6736(84)90164-8. [DOI] [PubMed] [Google Scholar]
  15. Triger D. R., Charlton C. A., Ward A. M. What does the antimitochondrial antibody mean? Gut. 1982 Oct;23(10):814–818. doi: 10.1136/gut.23.10.814. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES