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. 2000 Apr 15;347(Pt 2):321–337. doi: 10.1042/0264-6021:3470321

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

P Honkakoski 1, M Negishi 1
PMCID: PMC1220963  PMID: 10749660

Abstract

Members of the nuclear-receptor superfamily mediate crucial physiological functions by regulating the synthesis of their target genes. Nuclear receptors are usually activated by ligand binding. Cytochrome P450 (CYP) isoforms often catalyse both formation and degradation of these ligands. CYPs also metabolize many exogenous compounds, some of which may act as activators of nuclear receptors and disruptors of endocrine and cellular homoeostasis. This review summarizes recent findings that indicate that major classes of CYP genes are selectively regulated by certain ligand-activated nuclear receptors, thus creating tightly controlled networks.

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Selected References

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  1. Abu-Abed S. S., Beckett B. R., Chiba H., Chithalen J. V., Jones G., Metzger D., Chambon P., Petkovich M. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha. J Biol Chem. 1998 Jan 23;273(4):2409–2415. doi: 10.1074/jbc.273.4.2409. [DOI] [PubMed] [Google Scholar]
  2. Ahlgren R., Suske G., Waterman M. R., Lund J. Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene. J Biol Chem. 1999 Jul 2;274(27):19422–19428. doi: 10.1074/jbc.274.27.19422. [DOI] [PubMed] [Google Scholar]
  3. Aldridge T. C., Tugwood J. D., Green S. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem J. 1995 Mar 1;306(Pt 2):473–479. doi: 10.1042/bj3060473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Alexander D. L., Ganem L. G., Fernandez-Salguero P., Gonzalez F., Jefcoate C. R. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. J Cell Sci. 1998 Nov;111(Pt 22):3311–3322. doi: 10.1242/jcs.111.22.3311. [DOI] [PubMed] [Google Scholar]
  5. Alroy I., Towers T. L., Freedman L. P. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol. 1995 Oct;15(10):5789–5799. doi: 10.1128/mcb.15.10.5789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Andersson U., Yang Y. Z., Björkhem I., Einarsson C., Eggertsen G., Gåfvels M. Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene. Biochim Biophys Acta. 1999 May 18;1438(2):167–174. doi: 10.1016/s1388-1981(99)00036-0. [DOI] [PubMed] [Google Scholar]
  7. Andreola F., Fernandez-Salguero P. M., Chiantore M. V., Petkovich M. P., Gonzalez F. J., De Luca L. M. Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res. 1997 Jul 15;57(14):2835–2838. [PubMed] [Google Scholar]
  8. Angus W. G., Larsen M. C., Jefcoate C. R. Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. Carcinogenesis. 1999 Jun;20(6):947–955. doi: 10.1093/carcin/20.6.947. [DOI] [PubMed] [Google Scholar]
  9. Axén E., Postlind H., Sjöberg H., Wikvall K. Liver mitochondrial cytochrome P450 CYP27 and recombinant-expressed human CYP27 catalyze 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10014–10018. doi: 10.1073/pnas.91.21.10014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Baes M., Gulick T., Choi H. S., Martinoli M. G., Simha D., Moore D. D. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol. 1994 Mar;14(3):1544–1552. doi: 10.1128/mcb.14.3.1544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bakke M., Lund J. Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene. Mol Endocrinol. 1995 Mar;9(3):327–339. doi: 10.1210/mend.9.3.7776979. [DOI] [PubMed] [Google Scholar]
  12. Barwick J. L., Quattrochi L. C., Mills A. S., Potenza C., Tukey R. H., Guzelian P. S. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol. 1996 Jul;50(1):10–16. [PubMed] [Google Scholar]
  13. Beckman M. J., Tadikonda P., Werner E., Prahl J., Yamada S., DeLuca H. F. Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme. Biochemistry. 1996 Jun 25;35(25):8465–8472. doi: 10.1021/bi960658i. [DOI] [PubMed] [Google Scholar]
  14. Bertilsson G., Heidrich J., Svensson K., Asman M., Jendeberg L., Sydow-Bäckman M., Ohlsson R., Postlind H., Blomquist P., Berkenstam A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208–12213. doi: 10.1073/pnas.95.21.12208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Björkhem I., Diczfalusy U., Lütjohann D. Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr Opin Lipidol. 1999 Apr;10(2):161–165. doi: 10.1097/00041433-199904000-00010. [DOI] [PubMed] [Google Scholar]
  16. Blumberg B., Bolado J., Jr, Derguini F., Craig A. G., Moreno T. A., Chakravarti D., Heyman R. A., Buck J., Evans R. M. Novel retinoic acid receptor ligands in Xenopus embryos. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4873–4878. doi: 10.1073/pnas.93.10.4873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Blumberg B., Sabbagh W., Jr, Juguilon H., Bolado J., Jr, van Meter C. M., Ong E. S., Evans R. M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 1998 Oct 15;12(20):3195–3205. doi: 10.1101/gad.12.20.3195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Brake P. B., Zhang L., Jefcoate C. R. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Mol Pharmacol. 1998 Nov;54(5):825–833. doi: 10.1124/mol.54.5.825. [DOI] [PubMed] [Google Scholar]
  19. Brenza H. L., Kimmel-Jehan C., Jehan F., Shinki T., Wakino S., Anazawa H., Suda T., DeLuca H. F. Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1387–1391. doi: 10.1073/pnas.95.4.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Brown M. S., Goldstein J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997 May 2;89(3):331–340. doi: 10.1016/s0092-8674(00)80213-5. [DOI] [PubMed] [Google Scholar]
  21. Brzozowski A. M., Pike A. C., Dauter Z., Hubbard R. E., Bonn T., Engström O., Ohman L., Greene G. L., Gustafsson J. A., Carlquist M. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature. 1997 Oct 16;389(6652):753–758. doi: 10.1038/39645. [DOI] [PubMed] [Google Scholar]
  22. Bunone G., Briand P. A., Miksicek R. J., Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 1996 May 1;15(9):2174–2183. [PMC free article] [PubMed] [Google Scholar]
  23. Burger H. J., Schuetz J. D., Schuetz E. G., Guzelian P. S. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2145–2149. doi: 10.1073/pnas.89.6.2145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Cali J. J., Russell D. W. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J Biol Chem. 1991 Apr 25;266(12):7774–7778. [PubMed] [Google Scholar]
  25. Carlberg C. Mechanisms of nuclear signalling by vitamin D3. Interplay with retinoid and thyroid hormone signalling. Eur J Biochem. 1995 Aug 1;231(3):517–527. [PubMed] [Google Scholar]
  26. Carlberg C., Polly P. Gene regulation by vitamin D3. Crit Rev Eukaryot Gene Expr. 1998;8(1):19–42. doi: 10.1615/critreveukargeneexpr.v8.i1.20. [DOI] [PubMed] [Google Scholar]
  27. Carlone D. L., Richards J. S. Functional interactions, phosphorylation, and levels of 3',5'-cyclic adenosine monophosphate-regulatory element binding protein and steroidogenic factor-1 mediate hormone-regulated and constitutive expression of aromatase in gonadal cells. Mol Endocrinol. 1997 Mar;11(3):292–304. doi: 10.1210/mend.11.3.9900. [DOI] [PubMed] [Google Scholar]
  28. Carrier F., Owens R. A., Nebert D. W., Puga A. Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Mol Cell Biol. 1992 Apr;12(4):1856–1863. doi: 10.1128/mcb.12.4.1856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Castelein H., Declercq P. E., Baes M. DNA binding preferences of PPAR alpha/RXR alpha heterodimers. Biochem Biophys Res Commun. 1997 Apr 7;233(1):91–95. doi: 10.1006/bbrc.1997.6395. [DOI] [PubMed] [Google Scholar]
  30. Celander M., Weisbrod R., Stegeman J. J. Glucocorticoid potentiation of cytochrome P4501A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in porcine and human endothelial cells in culture. Biochem Biophys Res Commun. 1997 Mar 27;232(3):749–753. doi: 10.1006/bbrc.1997.6366. [DOI] [PubMed] [Google Scholar]
  31. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996 Jul;10(9):940–954. [PubMed] [Google Scholar]
  32. Chang T. K., Teixeira J., Gil G., Waxman D. J. The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation. Biochem J. 1993 Apr 15;291(Pt 2):429–433. doi: 10.1042/bj2910429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Chau Y. M., Crawford P. A., Woodson K. G., Polish J. A., Olson L. M., Sadovsky Y. Role of steroidogenic-factor 1 in basal and 3',5'-cyclic adenosine monophosphate-mediated regulation of cytochrome P450 side-chain cleavage enzyme in the mouse. Biol Reprod. 1997 Oct;57(4):765–771. doi: 10.1095/biolreprod57.4.765. [DOI] [PubMed] [Google Scholar]
  34. Chen D., Lepar G., Kemper B. A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J Biol Chem. 1994 Feb 18;269(7):5420–5427. [PubMed] [Google Scholar]
  35. Chen D., Park Y., Kemper B. Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes. DNA Cell Biol. 1994 Jul;13(7):771–779. doi: 10.1089/dna.1994.13.771. [DOI] [PubMed] [Google Scholar]
  36. Chen K. S., DeLuca H. F. Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. Biochim Biophys Acta. 1995 Jul 25;1263(1):1–9. doi: 10.1016/0167-4781(95)00060-t. [DOI] [PubMed] [Google Scholar]
  37. Chen Y. H., Tukey R. H. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J Biol Chem. 1996 Oct 18;271(42):26261–26266. doi: 10.1074/jbc.271.42.26261. [DOI] [PubMed] [Google Scholar]
  38. Choi H. S., Chung M., Tzameli I., Simha D., Lee Y. K., Seol W., Moore D. D. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J Biol Chem. 1997 Sep 19;272(38):23565–23571. doi: 10.1074/jbc.272.38.23565. [DOI] [PubMed] [Google Scholar]
  39. Christenson L. K., McAllister J. M., Martin K. O., Javitt N. B., Osborne T. F., Strauss J. F., 3rd Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. J Biol Chem. 1998 Nov 13;273(46):30729–30735. doi: 10.1074/jbc.273.46.30729. [DOI] [PubMed] [Google Scholar]
  40. Chu R., Madison L. D., Lin Y., Kopp P., Rao M. S., Jameson J. L., Reddy J. K. Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11593–11597. doi: 10.1073/pnas.92.25.11593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Corton J. C., Fan L. Q., Brown S., Anderson S. P., Bocos C., Cattley R. C., Mode A., Gustafsson J. A. Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals. Mol Pharmacol. 1998 Sep;54(3):463–473. doi: 10.1124/mol.54.3.463. [DOI] [PubMed] [Google Scholar]
  42. Crofts L. A., Hancock M. S., Morrison N. A., Eisman J. A. Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10529–10534. doi: 10.1073/pnas.95.18.10529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Darimont B. D., Wagner R. L., Apriletti J. W., Stallcup M. R., Kushner P. J., Baxter J. D., Fletterick R. J., Yamamoto K. R. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998 Nov 1;12(21):3343–3356. doi: 10.1101/gad.12.21.3343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. DeFranco D. B., Qi M., Borror K. C., Garabedian M. J., Brautigan D. L. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol Endocrinol. 1991 Sep;5(9):1215–1228. doi: 10.1210/mend-5-9-1215. [DOI] [PubMed] [Google Scholar]
  45. Denison M. S., Whitlock J. P., Jr Xenobiotic-inducible transcription of cytochrome P450 genes. J Biol Chem. 1995 Aug 4;270(31):18175–18178. doi: 10.1074/jbc.270.31.18175. [DOI] [PubMed] [Google Scholar]
  46. Devchand P. R., Keller H., Peters J. M., Vazquez M., Gonzalez F. J., Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature. 1996 Nov 7;384(6604):39–43. doi: 10.1038/384039a0. [DOI] [PubMed] [Google Scholar]
  47. Duester G. Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry. 1996 Sep 24;35(38):12221–12227. doi: 10.1021/bi961176+. [DOI] [PubMed] [Google Scholar]
  48. Emi Y., Omura T. Synthesis of sex-specific forms of cytochrome P-450 in rat liver is transiently suppressed by hepatic monooxygenase inducers. J Biochem. 1988 Jul;104(1):40–43. doi: 10.1093/oxfordjournals.jbchem.a122418. [DOI] [PubMed] [Google Scholar]
  49. Enmark E., Gustafsson J. A. Orphan nuclear receptors--the first eight years. Mol Endocrinol. 1996 Nov;10(11):1293–1307. doi: 10.1210/mend.10.11.8923456. [DOI] [PubMed] [Google Scholar]
  50. Fasco M. J. Estrogen receptor mRNA splice variants produced from the distal and proximal promoter transcripts. Mol Cell Endocrinol. 1998 Mar 16;138(1-2):51–59. doi: 10.1016/s0303-7207(98)00048-3. [DOI] [PubMed] [Google Scholar]
  51. Fernandez-Salguero P., Pineau T., Hilbert D. M., McPhail T., Lee S. S., Kimura S., Nebert D. W., Rudikoff S., Ward J. M., Gonzalez F. J. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science. 1995 May 5;268(5211):722–726. doi: 10.1126/science.7732381. [DOI] [PubMed] [Google Scholar]
  52. Fisher C. R., Graves K. H., Parlow A. F., Simpson E. R. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6965–6970. doi: 10.1073/pnas.95.12.6965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Forman B. M., Chen J., Evans R. M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312–4317. doi: 10.1073/pnas.94.9.4312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Forman B. M., Goode E., Chen J., Oro A. E., Bradley D. J., Perlmann T., Noonan D. J., Burka L. T., McMorris T., Lamph W. W. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell. 1995 Jun 2;81(5):687–693. doi: 10.1016/0092-8674(95)90530-8. [DOI] [PubMed] [Google Scholar]
  55. Forman B. M., Tzameli I., Choi H. S., Chen J., Simha D., Seol W., Evans R. M., Moore D. D. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 1998 Oct 8;395(6702):612–615. doi: 10.1038/26996. [DOI] [PubMed] [Google Scholar]
  56. Forrest D., Golarai G., Connor J., Curran T. Genetic analysis of thyroid hormone receptors in development and disease. Recent Prog Horm Res. 1996;51:1–22. [PubMed] [Google Scholar]
  57. Fraser J. D., Martinez V., Straney R., Briggs M. R. DNA binding and transcription activation specificity of hepatocyte nuclear factor 4. Nucleic Acids Res. 1998 Jun 1;26(11):2702–2707. doi: 10.1093/nar/26.11.2702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Frueh F. W., Zanger U. M., Meyer U. A. Extent and character of phenobarbital-mediated changes in gene expression in the liver. Mol Pharmacol. 1997 Mar;51(3):363–369. [PubMed] [Google Scholar]
  59. Furster C., Wikvall K. Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes. Biochim Biophys Acta. 1999 Jan 29;1437(1):46–52. doi: 10.1016/s0005-2760(98)00175-1. [DOI] [PubMed] [Google Scholar]
  60. Ganem L. G., Trottier E., Anderson A., Jefcoate C. R. Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers. Toxicol Appl Pharmacol. 1999 Feb 15;155(1):32–42. doi: 10.1006/taap.1998.8599. [DOI] [PubMed] [Google Scholar]
  61. Gierthy J. F., Spink B. C., Figge H. L., Pentecost B. T., Spink D. C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem. 1996 Feb;60(2):173–184. doi: 10.1002/(sici)1097-4644(19960201)60:2<173::aid-jcb2>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  62. Glass C. K., Rose D. W., Rosenfeld M. G. Nuclear receptor coactivators. Curr Opin Cell Biol. 1997 Apr;9(2):222–232. doi: 10.1016/s0955-0674(97)80066-x. [DOI] [PubMed] [Google Scholar]
  63. Gonzalez F. J., Lee Y. H. Constitutive expression of hepatic cytochrome P450 genes. FASEB J. 1996 Aug;10(10):1112–1117. doi: 10.1096/fasebj.10.10.8751713. [DOI] [PubMed] [Google Scholar]
  64. Gonzalez F. J., Peters J. M., Cattley R. C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J Natl Cancer Inst. 1998 Nov 18;90(22):1702–1709. doi: 10.1093/jnci/90.22.1702. [DOI] [PubMed] [Google Scholar]
  65. Goodwin B., Hodgson E., Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol. 1999 Dec;56(6):1329–1339. doi: 10.1124/mol.56.6.1329. [DOI] [PubMed] [Google Scholar]
  66. Gower D. B., Ruparelia B. A. Olfaction in humans with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact. J Endocrinol. 1993 May;137(2):167–187. doi: 10.1677/joe.0.1370167. [DOI] [PubMed] [Google Scholar]
  67. Grant P. A., Berger S. L. Histone acetyltransferase complexes. Semin Cell Dev Biol. 1999 Apr;10(2):169–177. doi: 10.1006/scdb.1999.0298. [DOI] [PubMed] [Google Scholar]
  68. Guengerich F. P. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chem Biol Interact. 1997 Oct 24;106(3):161–182. doi: 10.1016/s0009-2797(97)00068-9. [DOI] [PubMed] [Google Scholar]
  69. Göttlicher M., Widmark E., Li Q., Gustafsson J. A. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4653–4657. doi: 10.1073/pnas.89.10.4653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Hammer G. D., Krylova I., Zhang Y., Darimont B. D., Simpson K., Weigel N. L., Ingraham H. A. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell. 1999 Apr;3(4):521–526. doi: 10.1016/s1097-2765(00)80480-3. [DOI] [PubMed] [Google Scholar]
  71. Hankinson O. The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol. 1995;35:307–340. doi: 10.1146/annurev.pa.35.040195.001515. [DOI] [PubMed] [Google Scholar]
  72. Harder D. R., Campbell W. B., Roman R. J. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res. 1995 Mar-Apr;32(2):79–92. doi: 10.1159/000159080. [DOI] [PubMed] [Google Scholar]
  73. Hashimoto T., Matsumoto T., Nishizawa M., Kawabata S., Morohashi K., Handa S., Omura T. A mutant rat strain deficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes. J Biochem. 1988 Mar;103(3):487–492. doi: 10.1093/oxfordjournals.jbchem.a122297. [DOI] [PubMed] [Google Scholar]
  74. Hayes C. L., Spink D. C., Spink B. C., Cao J. Q., Walker N. J., Sutter T. R. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9776–9781. doi: 10.1073/pnas.93.18.9776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Hoivik D., Willett K., Wilson C., Safe S. Estrogen does not inhibit 2,3,7, 8-tetrachlorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells. J Biol Chem. 1997 Nov 28;272(48):30270–30274. doi: 10.1074/jbc.272.48.30270. [DOI] [PubMed] [Google Scholar]
  76. Honda S., Morohashi K., Nomura M., Takeya H., Kitajima M., Omura T. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J Biol Chem. 1993 Apr 5;268(10):7494–7502. [PubMed] [Google Scholar]
  77. Honda S., Morohashi K., Omura T. Novel cAMP regulatory elements in the promoter region of bovine P-450(11 beta) gene. J Biochem. 1990 Dec;108(6):1042–1049. doi: 10.1093/oxfordjournals.jbchem.a123303. [DOI] [PubMed] [Google Scholar]
  78. Honkakoski P., Kojo A., Lang M. A. Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochem J. 1992 Aug 1;285(Pt 3):979–983. doi: 10.1042/bj2850979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Honkakoski P., Lang M. A. Mouse liver phenobarbital-inducible P450 system: purification, characterization, and differential inducibility of four cytochrome P450 isozymes from D2 mouse. Arch Biochem Biophys. 1989 Aug 15;273(1):42–57. doi: 10.1016/0003-9861(89)90160-4. [DOI] [PubMed] [Google Scholar]
  80. Honkakoski P., Moore R., Gynther J., Negishi M. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. J Biol Chem. 1996 Apr 19;271(16):9746–9753. doi: 10.1074/jbc.271.16.9746. [DOI] [PubMed] [Google Scholar]
  81. Honkakoski P., Moore R., Washburn K. A., Negishi M. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol. 1998 Apr;53(4):597–601. doi: 10.1124/mol.53.4.597. [DOI] [PubMed] [Google Scholar]
  82. Honkakoski P., Negishi M. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J Biol Chem. 1997 Jun 6;272(23):14943–14949. doi: 10.1074/jbc.272.23.14943. [DOI] [PubMed] [Google Scholar]
  83. Honkakoski P., Negishi M. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem J. 1998 Mar 1;330(Pt 2):889–895. doi: 10.1042/bj3300889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Honkakoski P., Negishi M. Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J Biochem Mol Toxicol. 1998;12(1):3–9. doi: 10.1002/(sici)1099-0461(1998)12:1<3::aid-jbt2>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  85. Honkakoski P., Negishi M. The structure, function, and regulation of cytochrome P450 2A enzymes. Drug Metab Rev. 1997 Nov;29(4):977–996. doi: 10.3109/03602539709002240. [DOI] [PubMed] [Google Scholar]
  86. Honkakoski P., Zelko I., Sueyoshi T., Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol. 1998 Oct;18(10):5652–5658. doi: 10.1128/mcb.18.10.5652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Howell S. R., Shirley M. A., Ulm E. H. Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes. Drug Metab Dispos. 1998 Mar;26(3):234–239. [PubMed] [Google Scholar]
  88. Hsu M. H., Palmer C. N., Song W., Griffin K. J., Johnson E. F. A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding. J Biol Chem. 1998 Oct 23;273(43):27988–27997. doi: 10.1074/jbc.273.43.27988. [DOI] [PubMed] [Google Scholar]
  89. Huss J. M., Kasper C. B. Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. J Biol Chem. 1998 Jun 26;273(26):16155–16162. doi: 10.1074/jbc.273.26.16155. [DOI] [PubMed] [Google Scholar]
  90. Huss J. M., Wang S. I., Astrom A., McQuiddy P., Kasper C. B. Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4666–4670. doi: 10.1073/pnas.93.10.4666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Ibeanu G. C., Goldstein J. A. Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. Biochemistry. 1995 Jun 27;34(25):8028–8036. doi: 10.1021/bi00025a008. [DOI] [PubMed] [Google Scholar]
  92. Ignar-Trowbridge D. M., Nelson K. G., Bidwell M. C., Curtis S. W., Washburn T. F., McLachlan J. A., Korach K. S. Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4658–4662. doi: 10.1073/pnas.89.10.4658. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M. Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B). J Biochem. 1999 Jul;126(1):19–25. doi: 10.1093/oxfordjournals.jbchem.a022422. [DOI] [PubMed] [Google Scholar]
  94. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990 Oct 18;347(6294):645–650. doi: 10.1038/347645a0. [DOI] [PubMed] [Google Scholar]
  95. Jacob A. L., Lund J. Mutations in the activation function-2 core domain of steroidogenic factor-1 dominantly suppresses PKA-dependent transactivation of the bovine CYP17 gene. J Biol Chem. 1998 May 29;273(22):13391–13394. doi: 10.1074/jbc.273.22.13391. [DOI] [PubMed] [Google Scholar]
  96. Jaiswal A. K., Haaparanta T., Luc P. V., Schembri J., Adesnik M. Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene. Nucleic Acids Res. 1990 Jul 25;18(14):4237–4242. doi: 10.1093/nar/18.14.4237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Jana N. R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., Sone H. Role of estradiol receptor-alpha in differential expression of 2,3,7, 8-tetrachlorodibenzo-p-dioxin-inducible genes in the RL95-2 and KLE human endometrial cancer cell lines. Arch Biochem Biophys. 1999 Aug 1;368(1):31–39. doi: 10.1006/abbi.1999.1288. [DOI] [PubMed] [Google Scholar]
  98. Janowski B. A., Grogan M. J., Jones S. A., Wisely G. B., Kliewer S. A., Corey E. J., Mangelsdorf D. J. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266–271. doi: 10.1073/pnas.96.1.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Janowski B. A., Willy P. J., Devi T. R., Falck J. R., Mangelsdorf D. J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728–731. doi: 10.1038/383728a0. [DOI] [PubMed] [Google Scholar]
  100. Johansson L., Thomsen J. S., Damdimopoulos A. E., Spyrou G., Gustafsson J. A., Treuter E. The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta. J Biol Chem. 1999 Jan 1;274(1):345–353. doi: 10.1074/jbc.274.1.345. [DOI] [PubMed] [Google Scholar]
  101. Johnson C. A., Turner B. M. Histone deacetylases: complex transducers of nuclear signals. Semin Cell Dev Biol. 1999 Apr;10(2):179–188. doi: 10.1006/scdb.1999.0299. [DOI] [PubMed] [Google Scholar]
  102. Johnson E. F., Palmer C. N., Griffin K. J., Hsu M. H. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J. 1996 Sep;10(11):1241–1248. doi: 10.1096/fasebj.10.11.8836037. [DOI] [PubMed] [Google Scholar]
  103. Jones G., Strugnell S. A., DeLuca H. F. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998 Oct;78(4):1193–1231. doi: 10.1152/physrev.1998.78.4.1193. [DOI] [PubMed] [Google Scholar]
  104. Jow L., Mukherjee R. The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors. J Biol Chem. 1995 Feb 24;270(8):3836–3840. doi: 10.1074/jbc.270.8.3836. [DOI] [PubMed] [Google Scholar]
  105. Juge-Aubry C., Pernin A., Favez T., Burger A. G., Wahli W., Meier C. A., Desvergne B. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region. J Biol Chem. 1997 Oct 3;272(40):25252–25259. doi: 10.1074/jbc.272.40.25252. [DOI] [PubMed] [Google Scholar]
  106. Jurima-Romet M., Neigh S., Casley W. L. Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture. Hum Exp Toxicol. 1997 Apr;16(4):198–203. doi: 10.1177/096032719701600407. [DOI] [PubMed] [Google Scholar]
  107. Kagawa N., Waterman M. R. Purification and characterization of a transcription factor which appears to regulate cAMP responsiveness of the human CYP21B gene. J Biol Chem. 1992 Dec 15;267(35):25213–25219. [PubMed] [Google Scholar]
  108. Kastner P., Mark M., Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell. 1995 Dec 15;83(6):859–869. doi: 10.1016/0092-8674(95)90202-3. [DOI] [PubMed] [Google Scholar]
  109. Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol. 1999 Sep;19(9):6318–6322. doi: 10.1128/mcb.19.9.6318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Keeney D. S., Ikeda Y., Waterman M. R., Parker K. L. Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Mol Endocrinol. 1995 Aug;9(8):1091–1098. doi: 10.1210/mend.9.8.7476982. [DOI] [PubMed] [Google Scholar]
  111. Keeney D. S., Waterman M. R. Regulation of steroid hydroxylase gene expression: importance to physiology and disease. Pharmacol Ther. 1993 Jun;58(3):301–317. doi: 10.1016/0163-7258(93)90026-a. [DOI] [PubMed] [Google Scholar]
  112. Keller H., Devchand P. R., Perroud M., Wahli W. PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem. 1997 Jul;378(7):651–655. doi: 10.1515/bchm.1997.378.7.651. [DOI] [PubMed] [Google Scholar]
  113. Kende A. S., Ebetino F. H., Drendel W. B., Sundaralingam M., Glover E., Poland A. Structure-activity relationship of bispyridyloxybenzene for induction of mouse hepatic aminopyrine N-demethylase activity. Chemical, biological, and X-ray crystallographic studies. Mol Pharmacol. 1985 Nov;28(5):445–453. [PubMed] [Google Scholar]
  114. Kharat I., Saatcioglu F. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling. J Biol Chem. 1996 May 3;271(18):10533–10537. doi: 10.1074/jbc.271.18.10533. [DOI] [PubMed] [Google Scholar]
  115. Kim J. H., Stansbury K. H., Walker N. J., Trush M. A., Strickland P. T., Sutter T. R. Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis. 1998 Oct;19(10):1847–1853. doi: 10.1093/carcin/19.10.1847. [DOI] [PubMed] [Google Scholar]
  116. Kim J., Kemper B. Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin. J Biol Chem. 1997 Nov 21;272(47):29423–29425. doi: 10.1074/jbc.272.47.29423. [DOI] [PubMed] [Google Scholar]
  117. Kliewer S. A., Lehmann J. M., Willson T. M. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999 Apr 30;284(5415):757–760. doi: 10.1126/science.284.5415.757. [DOI] [PubMed] [Google Scholar]
  118. Kliewer S. A., Moore J. T., Wade L., Staudinger J. L., Watson M. A., Jones S. A., McKee D. D., Oliver B. B., Willson T. M., Zetterström R. H. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998 Jan 9;92(1):73–82. doi: 10.1016/s0092-8674(00)80900-9. [DOI] [PubMed] [Google Scholar]
  119. Kocarek T. A., Kraniak J. M., Reddy A. B. Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. Mol Pharmacol. 1998 Sep;54(3):474–484. doi: 10.1124/mol.54.3.474. [DOI] [PubMed] [Google Scholar]
  120. Kocarek T. A., Schuetz E. G., Guzelian P. S. Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. Mol Pharmacol. 1990 Oct;38(4):440–444. [PubMed] [Google Scholar]
  121. Kong X. F., Zhu X. H., Pei Y. L., Jackson D. M., Holick M. F. Molecular cloning, characterization, and promoter analysis of the human 25-hydroxyvitamin D3-1alpha-hydroxylase gene. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6988–6993. doi: 10.1073/pnas.96.12.6988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Korach K. S., Couse J. F., Curtis S. W., Washburn T. F., Lindzey J., Kimbro K. S., Eddy E. M., Migliaccio S., Snedeker S. M., Lubahn D. B. Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. Recent Prog Horm Res. 1996;51:159–188. [PubMed] [Google Scholar]
  123. Krishnan V., Porter W., Santostefano M., Wang X., Safe S. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol. 1995 Dec;15(12):6710–6719. doi: 10.1128/mcb.15.12.6710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Kumar M. B., Tarpey R. W., Perdew G. H. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem. 1999 Aug 6;274(32):22155–22164. doi: 10.1074/jbc.274.32.22155. [DOI] [PubMed] [Google Scholar]
  125. König H., Ponta H., Rahmsdorf H. J., Herrlich P. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J. 1992 Jun;11(6):2241–2246. doi: 10.1002/j.1460-2075.1992.tb05283.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Lala D. S., Ikeda Y., Luo X., Baity L. A., Meade J. C., Parker K. L. A cell-specific nuclear receptor regulates the steroid hydroxylases. Steroids. 1995 Jan;60(1):10–14. doi: 10.1016/0039-128x(94)00002-t. [DOI] [PubMed] [Google Scholar]
  127. Lala D. S., Syka P. M., Lazarchik S. B., Mangelsdorf D. J., Parker K. L., Heyman R. A. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895–4900. doi: 10.1073/pnas.94.10.4895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Lee S. S., Pineau T., Drago J., Lee E. J., Owens J. W., Kroetz D. L., Fernandez-Salguero P. M., Westphal H., Gonzalez F. J. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995 Jun;15(6):3012–3022. doi: 10.1128/mcb.15.6.3012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Lee Y. F., Young W. J., Lin W. J., Shyr C. R., Chang C. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem. 1999 Jun 4;274(23):16198–16205. doi: 10.1074/jbc.274.23.16198. [DOI] [PubMed] [Google Scholar]
  130. Legraverend C., Eguchi H., Ström A., Lahuna O., Mode A., Tollet P., Westin S., Gustafsson J. A. Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily. Biochemistry. 1994 Aug 23;33(33):9889–9897. doi: 10.1021/bi00199a010. [DOI] [PubMed] [Google Scholar]
  131. Legraverend C., Mode A., Westin S., Ström A., Eguchi H., Zaphiropoulos P. G., Gustafsson J. A. Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol Endocrinol. 1992 Feb;6(2):259–266. doi: 10.1210/mend.6.2.1569969. [DOI] [PubMed] [Google Scholar]
  132. Lehmann J. M., Kliewer S. A., Moore L. B., Smith-Oliver T. A., Oliver B. B., Su J. L., Sundseth S. S., Winegar D. A., Blanchard D. E., Spencer T. A. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137–3140. doi: 10.1074/jbc.272.6.3137. [DOI] [PubMed] [Google Scholar]
  133. Lehmann J. M., McKee D. D., Watson M. A., Willson T. M., Moore J. T., Kliewer S. A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest. 1998 Sep 1;102(5):1016–1023. doi: 10.1172/JCI3703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Leo M. A., Iida S., Lieber C. S. Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch Biochem Biophys. 1984 Oct;234(1):305–312. doi: 10.1016/0003-9861(84)90353-9. [DOI] [PubMed] [Google Scholar]
  135. Leo M. A., Lasker J. M., Raucy J. L., Kim C. I., Black M., Lieber C. S. Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8. Arch Biochem Biophys. 1989 Feb 15;269(1):305–312. doi: 10.1016/0003-9861(89)90112-4. [DOI] [PubMed] [Google Scholar]
  136. Leo M. A., Lieber C. S. New pathway for retinol metabolism in liver microsomes. J Biol Chem. 1985 May 10;260(9):5228–5231. [PubMed] [Google Scholar]
  137. Li H. C., Dehal S. S., Kupfer D. Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat. Effects on methoxychlor metabolism. J Biochem Toxicol. 1995 Feb;10(1):51–61. [PubMed] [Google Scholar]
  138. Li X. Y., Aström A., Duell E. A., Qin L., Griffiths C. E., Voorhees J. J. Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin. Carcinogenesis. 1995 Mar;16(3):519–524. doi: 10.1093/carcin/16.3.519. [DOI] [PubMed] [Google Scholar]
  139. Liang H. C., Li H., McKinnon R. A., Duffy J. J., Potter S. S., Puga A., Nebert D. W. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1671–1676. doi: 10.1073/pnas.93.4.1671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Liddle C., Goodwin B. J., George J., Tapner M., Farrell G. C. Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab. 1998 Jul;83(7):2411–2416. doi: 10.1210/jcem.83.7.4877. [DOI] [PubMed] [Google Scholar]
  141. Lin F. H., Stohs S. J., Birnbaum L. S., Clark G., Lucier G. W., Goldstein J. A. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. Toxicol Appl Pharmacol. 1991 Mar 15;108(1):129–139. doi: 10.1016/0041-008x(91)90276-k. [DOI] [PubMed] [Google Scholar]
  142. Linder M. W., Falkner K. C., Srinivasan G., Hines R. N., Prough R. A. Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor. Drug Metab Rev. 1999 Feb;31(1):247–271. doi: 10.1081/dmr-100101917. [DOI] [PubMed] [Google Scholar]
  143. Liu Z., Simpson E. R. Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression. Mol Cell Endocrinol. 1999 Jul 20;153(1-2):183–196. doi: 10.1016/s0303-7207(99)00036-2. [DOI] [PubMed] [Google Scholar]
  144. Liu Z., Simpson E. R. Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. Mol Endocrinol. 1997 Feb;11(2):127–137. doi: 10.1210/mend.11.2.9890. [DOI] [PubMed] [Google Scholar]
  145. Lorick K. L., Toscano D. L., Toscano W. A., Jr 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters retinoic acid receptor function in human keratinocytes. Biochem Biophys Res Commun. 1998 Feb 24;243(3):749–752. doi: 10.1006/bbrc.1998.8173. [DOI] [PubMed] [Google Scholar]
  146. Lund E. G., Guileyardo J. M., Russell D. W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7238–7243. doi: 10.1073/pnas.96.13.7238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  147. Lund E. G., Kerr T. A., Sakai J., Li W. P., Russell D. W. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem. 1998 Dec 18;273(51):34316–34327. doi: 10.1074/jbc.273.51.34316. [DOI] [PubMed] [Google Scholar]
  148. Luo X., Ikeda Y., Parker K. L. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell. 1994 May 20;77(4):481–490. doi: 10.1016/0092-8674(94)90211-9. [DOI] [PubMed] [Google Scholar]
  149. Lynch J. P., Lala D. S., Peluso J. J., Luo W., Parker K. L., White B. A. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol. 1993 Jun;7(6):776–786. doi: 10.1210/mend.7.6.8395654. [DOI] [PubMed] [Google Scholar]
  150. Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B. Identification of a nuclear receptor for bile acids. Science. 1999 May 21;284(5418):1362–1365. doi: 10.1126/science.284.5418.1362. [DOI] [PubMed] [Google Scholar]
  151. Maloney E. K., Waxman D. J. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209–218. doi: 10.1006/taap.1999.8809. [DOI] [PubMed] [Google Scholar]
  152. Mangelsdorf D. J., Evans R. M. The RXR heterodimers and orphan receptors. Cell. 1995 Dec 15;83(6):841–850. doi: 10.1016/0092-8674(95)90200-7. [DOI] [PubMed] [Google Scholar]
  153. Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P. The nuclear receptor superfamily: the second decade. Cell. 1995 Dec 15;83(6):835–839. doi: 10.1016/0092-8674(95)90199-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Martucci C. P., Fishman J. P450 enzymes of estrogen metabolism. Pharmacol Ther. 1993 Feb-Mar;57(2-3):237–257. doi: 10.1016/0163-7258(93)90057-k. [DOI] [PubMed] [Google Scholar]
  155. Mathis J. M., Houser W. H., Bresnick E., Cidlowski J. A., Hines R. N., Prough R. A., Simpson E. R. Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: receptor binding within intron I. Arch Biochem Biophys. 1989 Feb 15;269(1):93–105. doi: 10.1016/0003-9861(89)90090-8. [DOI] [PubMed] [Google Scholar]
  156. Mathis J. M., Prough R. A., Hines R. N., Bresnick E., Simpson E. R. Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Arch Biochem Biophys. 1986 Apr;246(1):439–448. doi: 10.1016/0003-9861(86)90490-x. [DOI] [PubMed] [Google Scholar]
  157. Meehan R. R., Forrester L. M., Stevenson K., Hastie N. D., Buchmann A., Kunz H. W., Wolf C. R. Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochem J. 1988 Sep 15;254(3):789–797. doi: 10.1042/bj2540789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. Meinke G., Sigler P. B. DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nat Struct Biol. 1999 May;6(5):471–477. doi: 10.1038/8276. [DOI] [PubMed] [Google Scholar]
  159. Mellon S. H., Bair S. R. 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1). Endocrinology. 1998 Jun;139(6):3026–3029. doi: 10.1210/endo.139.6.6129. [DOI] [PubMed] [Google Scholar]
  160. Meyer U. A., Zanger U. M. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol. 1997;37:269–296. doi: 10.1146/annurev.pharmtox.37.1.269. [DOI] [PubMed] [Google Scholar]
  161. Michael M. D., Kilgore M. W., Morohashi K., Simpson E. R. Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J Biol Chem. 1995 Jun 2;270(22):13561–13566. doi: 10.1074/jbc.270.22.13561. [DOI] [PubMed] [Google Scholar]
  162. Minucci S., Pelicci P. G. Retinoid receptors in health and disease: co-regulators and the chromatin connection. Semin Cell Dev Biol. 1999 Apr;10(2):215–225. doi: 10.1006/scdb.1999.0303. [DOI] [PubMed] [Google Scholar]
  163. Miyata K. S., McCaw S. E., Patel H. V., Rachubinski R. A., Capone J. P. The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J Biol Chem. 1996 Apr 19;271(16):9189–9192. doi: 10.1074/jbc.271.16.9189. [DOI] [PubMed] [Google Scholar]
  164. Moras D., Gronemeyer H. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol. 1998 Jun;10(3):384–391. doi: 10.1016/s0955-0674(98)80015-x. [DOI] [PubMed] [Google Scholar]
  165. Morohashi K., Honda S., Inomata Y., Handa H., Omura T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J Biol Chem. 1992 Sep 5;267(25):17913–17919. [PubMed] [Google Scholar]
  166. Mukai K., Mitani F., Shimada H., Ishimura Y. Involvement of an AP-1 complex in zone-specific expression of the CYP11B1 gene in the rat adrenal cortex. Mol Cell Biol. 1995 Nov;15(11):6003–6012. doi: 10.1128/mcb.15.11.6003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  167. Murayama A., Takeyama K., Kitanaka S., Kodera Y., Hosoya T., Kato S. The promoter of the human 25-hydroxyvitamin D3 1 alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3. Biochem Biophys Res Commun. 1998 Aug 10;249(1):11–16. doi: 10.1006/bbrc.1998.9098. [DOI] [PubMed] [Google Scholar]
  168. Mäkelä S., Savolainen H., Aavik E., Myllärniemi M., Strauss L., Taskinen E., Gustafsson J. A., Häyry P. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7077–7082. doi: 10.1073/pnas.96.12.7077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  169. Nakshatri H., Bhat-Nakshatri P. Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements. Nucleic Acids Res. 1998 May 15;26(10):2491–2499. doi: 10.1093/nar/26.10.2491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Nebert D. W. Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Mol Endocrinol. 1991 Sep;5(9):1203–1214. doi: 10.1210/mend-5-9-1203. [DOI] [PubMed] [Google Scholar]
  171. Negishi M., Uno T., Darden T. A., Sueyoshi T., Pedersen L. G. Structural flexibility and functional versatility of mammalian P450 enzymes. FASEB J. 1996 May;10(7):683–689. doi: 10.1096/fasebj.10.7.8635685. [DOI] [PubMed] [Google Scholar]
  172. Nelson D. R. Cytochrome P450 and the individuality of species. Arch Biochem Biophys. 1999 Sep 1;369(1):1–10. doi: 10.1006/abbi.1999.1352. [DOI] [PubMed] [Google Scholar]
  173. Nelson D. R., Koymans L., Kamataki T., Stegeman J. J., Feyereisen R., Waxman D. J., Waterman M. R., Gotoh O., Coon M. J., Estabrook R. W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 1996 Feb;6(1):1–42. doi: 10.1097/00008571-199602000-00002. [DOI] [PubMed] [Google Scholar]
  174. Nguyen T. A., Hoivik D., Lee J. E., Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch Biochem Biophys. 1999 Jul 15;367(2):250–257. doi: 10.1006/abbi.1999.1282. [DOI] [PubMed] [Google Scholar]
  175. Nitta M., Ku S., Brown C., Okamoto A. Y., Shan B. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6660–6665. doi: 10.1073/pnas.96.12.6660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  176. Nolte R. T., Wisely G. B., Westin S., Cobb J. E., Lambert M. H., Kurokawa R., Rosenfeld M. G., Willson T. M., Glass C. K., Milburn M. V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature. 1998 Sep 10;395(6698):137–143. doi: 10.1038/25931. [DOI] [PubMed] [Google Scholar]
  177. Nomura M., Kawabe K., Matsushita S., Oka S., Hatano O., Harada N., Nawata H., Morohashi K. Adrenocortical and gonadal expression of the mammalian Ftz-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control. J Biochem. 1998 Jul;124(1):217–224. doi: 10.1093/oxfordjournals.jbchem.a022083. [DOI] [PubMed] [Google Scholar]
  178. Noshiro M., Negishi M. Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver. J Biol Chem. 1986 Dec 5;261(34):15923–15927. [PubMed] [Google Scholar]
  179. Noshiro M., Nishimoto M., Morohashi K., Okuda K. Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression. FEBS Lett. 1989 Oct 23;257(1):97–100. doi: 10.1016/0014-5793(89)81795-8. [DOI] [PubMed] [Google Scholar]
  180. Ogino M., Nagata K., Miyata M., Yamazoe Y. Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3. Arch Biochem Biophys. 1999 Feb 1;362(1):32–37. doi: 10.1006/abbi.1998.1012. [DOI] [PubMed] [Google Scholar]
  181. Ohyama Y., Okuda K. Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3. J Biol Chem. 1991 May 15;266(14):8690–8695. [PubMed] [Google Scholar]
  182. Ohyama Y., Ozono K., Uchida M., Shinki T., Kato S., Suda T., Yamamoto O., Noshiro M., Kato Y. Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene. J Biol Chem. 1994 Apr 8;269(14):10545–10550. [PubMed] [Google Scholar]
  183. Omiecinski C. J. Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e. Nucleic Acids Res. 1986 Feb 11;14(3):1525–1539. doi: 10.1093/nar/14.3.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  184. Palmer C. N., Hsu M. H., Griffin H. J., Johnson E. F. Novel sequence determinants in peroxisome proliferator signaling. J Biol Chem. 1995 Jul 7;270(27):16114–16121. doi: 10.1074/jbc.270.27.16114. [DOI] [PubMed] [Google Scholar]
  185. Palmer C. N., Hsu M. H., Muerhoff A. S., Griffin K. J., Johnson E. F. Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. J Biol Chem. 1994 Jul 8;269(27):18083–18089. [PubMed] [Google Scholar]
  186. Park Y., Kemper B. The CYP2B1 proximal promoter contains a functional C/EBP regulatory element. DNA Cell Biol. 1996 Aug;15(8):693–701. doi: 10.1089/dna.1996.15.693. [DOI] [PubMed] [Google Scholar]
  187. Park Y., Li H., Kemper B. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J Biol Chem. 1996 Sep 27;271(39):23725–23728. doi: 10.1074/jbc.271.39.23725. [DOI] [PubMed] [Google Scholar]
  188. Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D. Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999 May 21;284(5418):1365–1368. doi: 10.1126/science.284.5418.1365. [DOI] [PubMed] [Google Scholar]
  189. Pascussi J. M., Jounaidi Y., Drocourt L., Domergue J., Balabaud C., Maurel P., Vilarem M. J. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun. 1999 Jul 5;260(2):377–381. doi: 10.1006/bbrc.1999.0745. [DOI] [PubMed] [Google Scholar]
  190. Peet D. J., Turley S. D., Ma W., Janowski B. A., Lobaccaro J. M., Hammer R. E., Mangelsdorf D. J. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998 May 29;93(5):693–704. doi: 10.1016/s0092-8674(00)81432-4. [DOI] [PubMed] [Google Scholar]
  191. Pereira T. M., Carlstedt-Duke J., Lechner M. C., Gustafsson J. A. Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene. DNA Cell Biol. 1998 Jan;17(1):39–49. doi: 10.1089/dna.1998.17.39. [DOI] [PubMed] [Google Scholar]
  192. Perlmann T., Umesono K., Rangarajan P. N., Forman B. M., Evans R. M. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors. Mol Endocrinol. 1996 Aug;10(8):958–966. doi: 10.1210/mend.10.8.8843412. [DOI] [PubMed] [Google Scholar]
  193. Peters J. M., Zhou Y. C., Ram P. A., Lee S. S., Gonzalez F. J., Waxman D. J. Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. Mol Pharmacol. 1996 Jul;50(1):67–74. [PubMed] [Google Scholar]
  194. Peterson J. A., Graham S. E. A close family resemblance: the importance of structure in understanding cytochromes P450. Structure. 1998 Sep 15;6(9):1079–1085. doi: 10.1016/s0969-2126(98)00109-9. [DOI] [PubMed] [Google Scholar]
  195. Pijnappel W. W., Folkers G. E., de Jonge W. J., Verdegem P. J., de Laat S. W., Lugtenburg J., Hendriks H. F., van der Saag P. T., Durston A. J. Metabolism to a response pathway selective retinoid ligand during axial pattern formation. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15424–15429. doi: 10.1073/pnas.95.26.15424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  196. Pikuleva I. A., Babiker A., Waterman M. R., Björkhem I. Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. J Biol Chem. 1998 Jul 17;273(29):18153–18160. doi: 10.1074/jbc.273.29.18153. [DOI] [PubMed] [Google Scholar]
  197. Plásilová M., Stoilov I., Sarfarazi M., Kádasi L., Feráková E., Ferák V. Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma. J Med Genet. 1999 Apr;36(4):290–294. [PMC free article] [PubMed] [Google Scholar]
  198. Postlind H., Axén E., Bergman T., Wikvall K. Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase. Biochem Biophys Res Commun. 1997 Dec 18;241(2):491–497. doi: 10.1006/bbrc.1997.7551. [DOI] [PubMed] [Google Scholar]
  199. Quattrochi L. C., Mills A. S., Barwick J. L., Yockey C. B., Guzelian P. S. A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J Biol Chem. 1995 Dec 1;270(48):28917–28923. doi: 10.1074/jbc.270.48.28917. [DOI] [PubMed] [Google Scholar]
  200. Ramsden R., Beck N. B., Sommer K. M., Omiecinski C. J. Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice. Gene. 1999 Mar 4;228(1-2):169–179. doi: 10.1016/s0378-1119(98)00612-x. [DOI] [PubMed] [Google Scholar]
  201. Ramsden R., Sommer K. M., Omiecinski C. J. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice. J Biol Chem. 1993 Oct 15;268(29):21722–21726. [PubMed] [Google Scholar]
  202. Raner G. M., Vaz A. D., Coon M. J. Metabolism of all-trans, 9-cis, and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P450 and mechanism-based inhibition of retinoid oxidation by citral. Mol Pharmacol. 1996 Mar;49(3):515–522. [PubMed] [Google Scholar]
  203. Rastinejad F., Perlmann T., Evans R. M., Sigler P. B. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 1995 May 18;375(6528):203–211. doi: 10.1038/375203a0. [DOI] [PubMed] [Google Scholar]
  204. Ray W. J., Bain G., Yao M., Gottlieb D. I. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. J Biol Chem. 1997 Jul 25;272(30):18702–18708. doi: 10.1074/jbc.272.30.18702. [DOI] [PubMed] [Google Scholar]
  205. Recent Advances in Steroid Biochemistry and Molecular Biology. Proceedings of the 12th International Symposium. Berlin, Germany, 21-24 May 1995. J Steroid Biochem Mol Biol. 1996 Jan;56(1-6):1–219. [PubMed] [Google Scholar]
  206. Reinholz G. G., DeLuca H. F. Inhibition of 25-hydroxyvitamin D3 production by 1, 25-dihydroxyvitamin D3 in rats. Arch Biochem Biophys. 1998 Jul 1;355(1):77–83. doi: 10.1006/abbi.1998.0706. [DOI] [PubMed] [Google Scholar]
  207. Rendic S., Di Carlo F. J. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev. 1997 Feb-May;29(1-2):413–580. doi: 10.3109/03602539709037591. [DOI] [PubMed] [Google Scholar]
  208. Ricci M. S., Toscano D. G., Mattingly C. J., Toscano W. A., Jr Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells. J Biol Chem. 1999 Feb 5;274(6):3430–3438. doi: 10.1074/jbc.274.6.3430. [DOI] [PubMed] [Google Scholar]
  209. Rifkind A. B., Lee C., Chang T. K., Waxman D. J. Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys. 1995 Jul 10;320(2):380–389. doi: 10.1016/0003-9861(95)90023-3. [DOI] [PubMed] [Google Scholar]
  210. Roberts E. S., Vaz A. D., Coon M. J. Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol Pharmacol. 1992 Feb;41(2):427–433. [PubMed] [Google Scholar]
  211. Roman L. J., Palmer C. N., Clark J. E., Muerhoff A. S., Griffin K. J., Johnson E. F., Masters B. S. Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins. Arch Biochem Biophys. 1993 Nov 15;307(1):57–65. doi: 10.1006/abbi.1993.1560. [DOI] [PubMed] [Google Scholar]
  212. Rose K. A., Stapleton G., Dott K., Kieny M. P., Best R., Schwarz M., Russell D. W., Björkhem I., Seckl J., Lathe R. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4925–4930. doi: 10.1073/pnas.94.10.4925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  213. Roselli C. E., Klosterman S. A. Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology. 1998 Jul;139(7):3193–3201. doi: 10.1210/endo.139.7.6101. [DOI] [PubMed] [Google Scholar]
  214. Rosen H., Reshef A., Maeda N., Lippoldt A., Shpizen S., Triger L., Eggertsen G., Björkhem I., Leitersdorf E. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J Biol Chem. 1998 Jun 12;273(24):14805–14812. doi: 10.1074/jbc.273.24.14805. [DOI] [PubMed] [Google Scholar]
  215. Rozman D., Strömstedt M., Tsui L. C., Scherer S. W., Waterman M. R. Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics. 1996 Dec 15;38(3):371–381. doi: 10.1006/geno.1996.0640. [DOI] [PubMed] [Google Scholar]
  216. Russell D. W. Nuclear orphan receptors control cholesterol catabolism. Cell. 1999 May 28;97(5):539–542. doi: 10.1016/s0092-8674(00)80763-1. [DOI] [PubMed] [Google Scholar]
  217. Russell D. W., Setchell K. D. Bile acid biosynthesis. Biochemistry. 1992 May 26;31(20):4737–4749. doi: 10.1021/bi00135a001. [DOI] [PubMed] [Google Scholar]
  218. Sadovsky Y., Crawford P. A., Woodson K. G., Polish J. A., Clements M. A., Tourtellotte L. M., Simburger K., Milbrandt J. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10939–10943. doi: 10.1073/pnas.92.24.10939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  219. Safe S., Wang F., Porter W., Duan R., McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett. 1998 Dec 28;102-103:343–347. doi: 10.1016/s0378-4274(98)00331-2. [DOI] [PubMed] [Google Scholar]
  220. Schmiedlin-Ren P., Thummel K. E., Fisher J. M., Paine M. F., Lown K. S., Watkins P. B. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. Mol Pharmacol. 1997 May;51(5):741–754. doi: 10.1124/mol.51.5.741. [DOI] [PubMed] [Google Scholar]
  221. Schuetz E. G., Brimer C., Schuetz J. D. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol Pharmacol. 1998 Dec;54(6):1113–1117. doi: 10.1124/mol.54.6.1113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  222. Schuetz J. D., Beach D. L., Guzelian P. S. Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. Pharmacogenetics. 1994 Feb;4(1):11–20. doi: 10.1097/00008571-199402000-00002. [DOI] [PubMed] [Google Scholar]
  223. Schuetz J. D., Schuetz E. G., Thottassery J. V., Guzelian P. S., Strom S., Sun D. Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol. 1996 Jan;49(1):63–72. [PubMed] [Google Scholar]
  224. Schwarz M., Lund E. G., Lathe R., Björkhem I., Russell D. W. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J Biol Chem. 1997 Sep 19;272(38):23995–24001. doi: 10.1074/jbc.272.38.23995. [DOI] [PubMed] [Google Scholar]
  225. Seol W., Choi H. S., Moore D. D. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336–1339. doi: 10.1126/science.272.5266.1336. [DOI] [PubMed] [Google Scholar]
  226. Setchell K. D., Schwarz M., O'Connell N. C., Lund E. G., Davis D. L., Lathe R., Thompson H. R., Weslie Tyson R., Sokol R. J., Russell D. W. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J Clin Invest. 1998 Nov 1;102(9):1690–1703. doi: 10.1172/JCI2962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  227. Sewall C. H., Flagler N., Vanden Heuvel J. P., Clark G. C., Tritscher A. M., Maronpot R. M., Lucier G. W. Alterations in thyroid function in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1995 Jun;132(2):237–244. doi: 10.1006/taap.1995.1104. [DOI] [PubMed] [Google Scholar]
  228. Shao D., Lazar M. A. Modulating nuclear receptor function: may the phos be with you. J Clin Invest. 1999 Jun;103(12):1617–1618. doi: 10.1172/JCI7421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  229. Shao D., Rangwala S. M., Bailey S. T., Krakow S. L., Reginato M. J., Lazar M. A. Interdomain communication regulating ligand binding by PPAR-gamma. Nature. 1998 Nov 26;396(6709):377–380. doi: 10.1038/24634. [DOI] [PubMed] [Google Scholar]
  230. Sharma R., Lake B. G., Gibson G. G. Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies. Biochem Pharmacol. 1988 Apr 1;37(7):1203–1206. doi: 10.1016/0006-2952(88)90771-x. [DOI] [PubMed] [Google Scholar]
  231. Sherratt A. J., Banet D. E., Linder M. W., Prough R. A. Potentiation of 3-methylcholanthrene induction of rat hepatic cytochrome P450IA1 by dexamethasone in vivo. J Pharmacol Exp Ther. 1989 May;249(2):667–672. [PubMed] [Google Scholar]
  232. Sidhu J. S., Omiecinski C. J. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J Pharmacol Exp Ther. 1997 Aug;282(2):1122–1129. [PubMed] [Google Scholar]
  233. Sidhu J. S., Omiecinski C. J. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics. 1995 Feb;5(1):24–36. doi: 10.1097/00008571-199502000-00003. [DOI] [PubMed] [Google Scholar]
  234. Sidhu J. S., Omiecinski C. J. Protein synthesis inhibitors exhibit a nonspecific effect on phenobarbital-inducible cytochome P450 gene expression in primary rat hepatocytes. J Biol Chem. 1998 Feb 20;273(8):4769–4775. doi: 10.1074/jbc.273.8.4769. [DOI] [PubMed] [Google Scholar]
  235. Spink B. C., Fasco M. J., Gierthy J. F., Spink D. C. 12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells. J Cell Biochem. 1998 Sep 1;70(3):289–296. [PubMed] [Google Scholar]
  236. St-Arnaud R. Targeted inactivation of vitamin D hydroxylases in mice. Bone. 1999 Jul;25(1):127–129. doi: 10.1016/s8756-3282(99)00118-0. [DOI] [PubMed] [Google Scholar]
  237. Stravitz R. T., Vlahcevic Z. R., Russell T. L., Heizer M. L., Avadhani N. G., Hylemon P. B. Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes. J Steroid Biochem Mol Biol. 1996 Mar;57(5-6):337–347. doi: 10.1016/0960-0760(95)00282-0. [DOI] [PubMed] [Google Scholar]
  238. Stresser D. M., Kupfer D. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation. Drug Metab Dispos. 1998 Sep;26(9):868–874. [PubMed] [Google Scholar]
  239. Stroup D., Crestani M., Chiang J. Y. Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A. Am J Physiol. 1997 Aug;273(2 Pt 1):G508–G517. doi: 10.1152/ajpgi.1997.273.2.G508. [DOI] [PubMed] [Google Scholar]
  240. Stroup D., Crestani M., Chiang J. Y. Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A). J Biol Chem. 1997 Apr 11;272(15):9833–9839. doi: 10.1074/jbc.272.15.9833. [DOI] [PubMed] [Google Scholar]
  241. Ström A., Westin S., Eguchi H., Gustafsson J. A., Mode A. Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver. J Biol Chem. 1995 May 12;270(19):11276–11281. doi: 10.1074/jbc.270.19.11276. [DOI] [PubMed] [Google Scholar]
  242. Strömstedt M., Rozman D., Waterman M. R. The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch Biochem Biophys. 1996 May 1;329(1):73–81. doi: 10.1006/abbi.1996.0193. [DOI] [PubMed] [Google Scholar]
  243. Strömstedt M., Waterman M. R., Haugen T. B., Taskén K., Parvinen M., Rozman D. Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats. Endocrinology. 1998 May;139(5):2314–2321. doi: 10.1210/endo.139.5.5984. [DOI] [PubMed] [Google Scholar]
  244. Strömstedt M., Waterman M. R. Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain. Brain Res Mol Brain Res. 1995 Dec 1;34(1):75–88. doi: 10.1016/0169-328x(95)00140-n. [DOI] [PubMed] [Google Scholar]
  245. Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem. 1999 Mar 5;274(10):6043–6046. doi: 10.1074/jbc.274.10.6043. [DOI] [PubMed] [Google Scholar]
  246. Sueyoshi T., Yokomori N., Korach K. S., Negishi M. Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver. Mol Pharmacol. 1999 Sep;56(3):473–477. doi: 10.1124/mol.56.3.473. [DOI] [PubMed] [Google Scholar]
  247. Sunahara G. I., Guenat C., Grieu F. Characterization of 3-methylcholanthrene effects on the rat glucocorticoid receptor in vivo. Cancer Res. 1989 Jul 1;49(13):3535–3541. [PubMed] [Google Scholar]
  248. Sundseth S. S., Alberta J. A., Waxman D. J. Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J Biol Chem. 1992 Feb 25;267(6):3907–3914. [PubMed] [Google Scholar]
  249. Takeyama K., Kitanaka S., Sato T., Kobori M., Yanagisawa J., Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. 1997 Sep 19;277(5333):1827–1830. doi: 10.1126/science.277.5333.1827. [DOI] [PubMed] [Google Scholar]
  250. Tanenbaum D. M., Wang Y., Williams S. P., Sigler P. B. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5998–6003. doi: 10.1073/pnas.95.11.5998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  251. Taningher M., Malacarne D., Izzotti A., Ugolini D., Parodi S. Drug metabolism polymorphisms as modulators of cancer susceptibility. Mutat Res. 1999 May;436(3):227–261. doi: 10.1016/s1383-5742(99)00005-8. [DOI] [PubMed] [Google Scholar]
  252. Thomsen J. S., Wang X., Hines R. N., Safe S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis. 1994 May;15(5):933–937. doi: 10.1093/carcin/15.5.933. [DOI] [PubMed] [Google Scholar]
  253. Thummel K. E., Wilkinson G. R. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol. 1998;38:389–430. doi: 10.1146/annurev.pharmtox.38.1.389. [DOI] [PubMed] [Google Scholar]
  254. Traber P. G., Wang W., McDonnell M., Gumucio J. J. P450IIB gene expression in rat small intestine: cloning of intestinal P450IIB1 mRNA using the polymerase chain reaction and transcriptional regulation of induction. Mol Pharmacol. 1990 Jun;37(6):810–819. [PubMed] [Google Scholar]
  255. Trottier E., Belzil A., Stoltz C., Anderson A. Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene. Gene. 1995 Jun 9;158(2):263–268. doi: 10.1016/0378-1119(94)00916-g. [DOI] [PubMed] [Google Scholar]
  256. Twisk J., de Wit E. C., Princen H. M. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes. Biochem J. 1995 Jan 15;305(Pt 2):505–511. doi: 10.1042/bj3050505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  257. Udy G. B., Towers R. P., Snell R. G., Wilkins R. J., Park S. H., Ram P. A., Waxman D. J., Davey H. W. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7239–7244. doi: 10.1073/pnas.94.14.7239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  258. Umesono K., Murakami K. K., Thompson C. C., Evans R. M. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell. 1991 Jun 28;65(7):1255–1266. doi: 10.1016/0092-8674(91)90020-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
  259. Vamecq J., Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet. 1999 Jul 10;354(9173):141–148. doi: 10.1016/S0140-6736(98)10364-1. [DOI] [PubMed] [Google Scholar]
  260. Vanacker J. M., Bonnelye E., Chopin-Delannoy S., Delmarre C., Cavaillès V., Laudet V. Transcriptional activities of the orphan nuclear receptor ERR alpha (estrogen receptor-related receptor-alpha). Mol Endocrinol. 1999 May;13(5):764–773. doi: 10.1210/mend.13.5.0281. [DOI] [PubMed] [Google Scholar]
  261. Vanacker J. M., Pettersson K., Gustafsson J. A., Laudet V. Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta. EMBO J. 1999 Aug 2;18(15):4270–4279. doi: 10.1093/emboj/18.15.4270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  262. Vecchini F., Lenoir-Viale M. C., Cathelineau C., Magdalou J., Bernard B. A., Shroot B. Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1205–1212. doi: 10.1006/bbrc.1994.1833. [DOI] [PubMed] [Google Scholar]
  263. Vecchini F., Mace K., Magdalou J., Mahe Y., Bernard B. A., Shroot B. Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes. Br J Dermatol. 1995 Jan;132(1):14–21. doi: 10.1111/j.1365-2133.1995.tb08618.x. [DOI] [PubMed] [Google Scholar]
  264. Venepally P., Chen D., Kemper B. Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes. J Biol Chem. 1992 Aug 25;267(24):17333–17338. [PubMed] [Google Scholar]
  265. Wagner R. L., Apriletti J. W., McGrath M. E., West B. L., Baxter J. D., Fletterick R. J. A structural role for hormone in the thyroid hormone receptor. Nature. 1995 Dec 14;378(6558):690–697. doi: 10.1038/378690a0. [DOI] [PubMed] [Google Scholar]
  266. Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell. 1999 May;3(5):543–553. doi: 10.1016/s1097-2765(00)80348-2. [DOI] [PubMed] [Google Scholar]
  267. Wang X., Porter W., Krishnan V., Narasimhan T. R., Safe S. Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Mol Cell Endocrinol. 1993 Oct;96(1-2):159–166. doi: 10.1016/0303-7207(93)90106-t. [DOI] [PubMed] [Google Scholar]
  268. Wanner R., Brömmer S., Czarnetzki B. M., Rosenbach T. The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid. Biochem Biophys Res Commun. 1995 Apr 17;209(2):706–711. doi: 10.1006/bbrc.1995.1556. [DOI] [PubMed] [Google Scholar]
  269. Waterman M. R., Bischof L. J. Mechanisms of ACTH(cAMP)-dependent transcription of adrenal steroid hydroxylases. Endocr Res. 1996 Nov;22(4):615–620. doi: 10.1080/07435809609043755. [DOI] [PubMed] [Google Scholar]
  270. Waxman D. J., Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem J. 1992 Feb 1;281(Pt 3):577–592. doi: 10.1042/bj2810577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  271. Waxman D. J. Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochem Pharmacol. 1988 Jan 1;37(1):71–84. doi: 10.1016/0006-2952(88)90756-3. [DOI] [PubMed] [Google Scholar]
  272. Waxman D. J. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys. 1999 Sep 1;369(1):11–23. doi: 10.1006/abbi.1999.1351. [DOI] [PubMed] [Google Scholar]
  273. Webb S. J., Xiao G. H., Geoghegan T. E., Prough R. A. Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone. Mol Pharmacol. 1996 Feb;49(2):276–287. [PubMed] [Google Scholar]
  274. Weigel N. L. Steroid hormone receptors and their regulation by phosphorylation. Biochem J. 1996 Nov 1;319(Pt 3):657–667. doi: 10.1042/bj3190657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  275. Westin S., Mode A., Murray M., Chen R., Gustafsson J. A. Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes. Mol Pharmacol. 1993 Nov;44(5):997–1002. [PubMed] [Google Scholar]
  276. Westin S., Sonneveld E., van der Leede B. M., van der Saag P. T., Gustafsson J. A., Mode A. CYP2C7 expression in rat liver and hepatocytes: regulation by retinoids. Mol Cell Endocrinol. 1997 May 16;129(2):169–179. doi: 10.1016/s0303-7207(97)04055-0. [DOI] [PubMed] [Google Scholar]
  277. White J. A., Beckett-Jones B., Guo Y. D., Dilworth F. J., Bonasoro J., Jones G., Petkovich M. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem. 1997 Jul 25;272(30):18538–18541. doi: 10.1074/jbc.272.30.18538. [DOI] [PubMed] [Google Scholar]
  278. White P. C. Genetic diseases of steroid metabolism. Vitam Horm. 1994;49:131–195. doi: 10.1016/s0083-6729(08)61147-4. [DOI] [PubMed] [Google Scholar]
  279. Willy P. J., Umesono K., Ong E. S., Evans R. M., Heyman R. A., Mangelsdorf D. J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 1995 May 1;9(9):1033–1045. doi: 10.1101/gad.9.9.1033. [DOI] [PubMed] [Google Scholar]
  280. Wilson T. E., Mouw A. R., Weaver C. A., Milbrandt J., Parker K. L. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol. 1993 Feb;13(2):861–868. doi: 10.1128/mcb.13.2.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  281. Xu G., Salen G., Shefer S., Tint G. S., Nguyen L. B., Chen T. S., Greenblatt D. Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis. J Clin Invest. 1999 Jan;103(1):89–95. doi: 10.1172/JCI4414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  282. Xu L., Glass C. K., Rosenfeld M. G. Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev. 1999 Apr;9(2):140–147. doi: 10.1016/S0959-437X(99)80021-5. [DOI] [PubMed] [Google Scholar]
  283. Yan Z. H., Karam W. G., Staudinger J. L., Medvedev A., Ghanayem B. I., Jetten A. M. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J Biol Chem. 1998 May 1;273(18):10948–10957. doi: 10.1074/jbc.273.18.10948. [DOI] [PubMed] [Google Scholar]
  284. Yang C., Zhou D., Chen S. Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor. Cancer Res. 1998 Dec 15;58(24):5695–5700. [PubMed] [Google Scholar]
  285. Yeowell H. N., Waxman D. J., Wadhera A., Goldstein J. A. Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. Mol Pharmacol. 1987 Sep;32(3):340–347. [PubMed] [Google Scholar]
  286. Yokomori N., Nishio K., Aida K., Negishi M. Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver. J Steroid Biochem Mol Biol. 1997 Jul;62(4):307–314. doi: 10.1016/s0960-0760(97)00048-4. [DOI] [PubMed] [Google Scholar]
  287. Yong E. L., Tut T. G., Ghadessy F. J., Prins G., Ratnam S. S. Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain. Mol Cell Endocrinol. 1998 Feb;137(1):41–50. doi: 10.1016/s0303-7207(97)00229-3. [DOI] [PubMed] [Google Scholar]
  288. Yoshida Y., Yamashita C., Noshiro M., Fukuda M., Aoyama Y. Sterol 14-demethylase P450 activity expressed in rat gonads: contribution to the formation of mammalian meiosis-activating sterol. Biochem Biophys Res Commun. 1996 Jun 25;223(3):534–538. doi: 10.1006/bbrc.1996.0929. [DOI] [PubMed] [Google Scholar]
  289. Yoshioka H., Lang M., Wong G., Negishi M. A specific cis-acting element regulates in vitro transcription of sex-dependent mouse steroid 16 alpha-hydroxylase (C-P450(16 alpha)) gene. J Biol Chem. 1990 Aug 25;265(24):14612–14617. [PubMed] [Google Scholar]
  290. Yu K., Bayona W., Kallen C. B., Harding H. P., Ravera C. P., McMahon G., Brown M., Lazar M. A. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem. 1995 Oct 13;270(41):23975–23983. doi: 10.1074/jbc.270.41.23975. [DOI] [PubMed] [Google Scholar]
  291. Zechel C., Shen X. Q., Chambon P., Gronemeyer H. Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements. EMBO J. 1994 Mar 15;13(6):1414–1424. doi: 10.1002/j.1460-2075.1994.tb06395.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  292. Zhang H., LeCulyse E., Liu L., Hu M., Matoney L., Zhu W., Yan B. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys. 1999 Aug 1;368(1):14–22. doi: 10.1006/abbi.1999.1307. [DOI] [PubMed] [Google Scholar]
  293. Zhang P., Hammer F., Bair S., Wang J., Reeves W. H., Mellon S. H. Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription. DNA Cell Biol. 1999 Mar;18(3):197–208. doi: 10.1089/104454999315411. [DOI] [PubMed] [Google Scholar]
  294. Zhang P., Mellon S. H. Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action. Mol Endocrinol. 1997 Jun;11(7):891–904. doi: 10.1210/mend.11.7.9940. [DOI] [PubMed] [Google Scholar]
  295. Zhang Q. Y., Raner G., Ding X., Dunbar D., Coon M. J., Kaminsky L. S. Characterization of the cytochrome P450 CYP2J4: expression in rat small intestine and role in retinoic acid biotransformation from retinal. Arch Biochem Biophys. 1998 May 15;353(2):257–264. doi: 10.1006/abbi.1998.0654. [DOI] [PubMed] [Google Scholar]
  296. Zhu X. G., Hanover J. A., Hager G. L., Cheng S. Y. Hormone-induced translocation of thyroid hormone receptors in living cells visualized using a receptor green fluorescent protein chimera. J Biol Chem. 1998 Oct 16;273(42):27058–27063. doi: 10.1074/jbc.273.42.27058. [DOI] [PubMed] [Google Scholar]
  297. Zou A., Elgort M. G., Allegretto E. A. Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3. J Biol Chem. 1997 Jul 25;272(30):19027–19034. doi: 10.1074/jbc.272.30.19027. [DOI] [PubMed] [Google Scholar]
  298. vom Baur E., Zechel C., Heery D., Heine M. J., Garnier J. M., Vivat V., Le Douarin B., Gronemeyer H., Chambon P., Losson R. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110–124. [PMC free article] [PubMed] [Google Scholar]

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