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. 1990 Mar;84:149–153. doi: 10.1289/ehp.9084149

Impact of halogenated compounds on calcium homeostasis in hepatocytes.

L Moore 1, D R Schoenberg 1, R M Long 1
PMCID: PMC1567645  PMID: 2190809

Abstract

Halocarbons (CCl4, 1,1-dichlorethylene) cause a wide spectrum of effects and injury in hepatocytes. One early effect of these compounds is the inhibition and destruction of the endoplasmic reticulum (ER) calcium pump. Subsequent to inhibition of this pump, the ER calcium pool is depleted and cytosolic levels of calcium are increased for a prolonged period of time. This effect of halocarbons has been characterized and is similar in vivo and in vitro. The importance of this redistribution of cell calcium in expression of halocarbon injury of hepatocytes has not been fully resolved. Several degradative enzymes (phospholipases, proteases) have been implicated as calcium-dependent mediators in toxicity. Our preliminary studies of the effect of calcium redistribution suggest that activation of a calcium-sensitive endonuclease in liver does not play a central role in initiating the lethal effect of halocarbons on hepatocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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