Skip to main content
American Journal of Public Health logoLink to American Journal of Public Health
. 1987 May;77(5):623–625. doi: 10.2105/ajph.77.5.623

Maternal cigarette smoking and oral clefts: a population-based study.

M J Khoury, A Weinstein, S Panny, N A Holtzman, P K Lindsay, K Farrel, M Eisenberg
PMCID: PMC1647050  PMID: 3565662

Abstract

Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding variables did not account for the association between smoking and oral clefts.

Full text

PDF
625

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alberman E. D., Goldstein H. Possible teratogenic effect of cigarette smoking. Nature. 1971 Jun 25;231(5304):529–530. doi: 10.1038/231529a0. [DOI] [PubMed] [Google Scholar]
  2. Andrews J., McGarry J. M. A community study of smoking in pregnancy. J Obstet Gynaecol Br Commonw. 1972 Dec;79(12):1057–1073. doi: 10.1111/j.1471-0528.1972.tb11887.x. [DOI] [PubMed] [Google Scholar]
  3. Aro T. Maternal diseases, alcohol consumption and smoking during pregnancy associated with reduction limb defects. Early Hum Dev. 1983 Dec;9(1):49–57. doi: 10.1016/0378-3782(83)90101-9. [DOI] [PubMed] [Google Scholar]
  4. Christianson R. E. The relationship between maternal smoking and the incidence of congenital anomalies. Am J Epidemiol. 1980 Nov;112(5):684–695. doi: 10.1093/oxfordjournals.aje.a113041. [DOI] [PubMed] [Google Scholar]
  5. Comstock G. W., Shah F. K., Meyer M. B., Abbey H. Low birth weight and neonatal mortality rate related to maternal smoking and socioeconomic status. Am J Obstet Gynecol. 1971 Sep;111(1):53–59. doi: 10.1016/0002-9378(71)90926-4. [DOI] [PubMed] [Google Scholar]
  6. Emanuel I., Culver B. H., Erickson J. D., Guthrie B., Schuldberg D. The further epidemiological differentiation of cleft lip and palate: a population study of clefts in King County, Washington, 1956-1965. Teratology. 1973 Jun;7(3):271–281. doi: 10.1002/tera.1420070308. [DOI] [PubMed] [Google Scholar]
  7. Ericson A., Källén B., Westerholm P. Cigarette smoking as an etiologic factor in cleft lip and palate. Am J Obstet Gynecol. 1979 Oct 1;135(3):348–351. doi: 10.1016/0002-9378(79)90703-8. [DOI] [PubMed] [Google Scholar]
  8. Evans D. R., Newcombe R. G., Campbell H. Maternal smoking habits and congenital malformations: a population study. Br Med J. 1979 Jul 21;2(6183):171–173. doi: 10.1136/bmj.2.6183.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hemminki K., Mutanen P., Saloniemi I. Smoking and the occurrence of congenital malformations and spontaneous abortions: multivariate analysis. Am J Obstet Gynecol. 1983 Jan 1;145(1):61–66. doi: 10.1016/0002-9378(83)90340-x. [DOI] [PubMed] [Google Scholar]
  10. Himmelberger D. U., Brown B. W., Jr, cohen E. N. Cigarette smoking during pregnancy and the occurrence of spontaneous abortion and congenital abnormality. Am J Epidemiol. 1978 Dec;108(6):470–479. doi: 10.1093/oxfordjournals.aje.a112645. [DOI] [PubMed] [Google Scholar]
  11. Holmes L. B., Driscoll S. G., Atkins L. Etiologic heterogeneity of neural-tube defects. N Engl J Med. 1976 Feb 12;294(7):365–369. doi: 10.1056/NEJM197602122940704. [DOI] [PubMed] [Google Scholar]
  12. Hook E. B., Cross P. K. Cigarette smoking and Down syndrome. Am J Hum Genet. 1985 Nov;37(6):1216–1224. [PMC free article] [PubMed] [Google Scholar]
  13. Johnston C. Cigarette smoking and the outcome of human pregnancies: a status report on the consequences. Clin Toxicol. 1981 Feb;18(2):189–209. doi: 10.3109/15563658108990026. [DOI] [PubMed] [Google Scholar]
  14. Kelsey J. L., Dwyer T., Holford T. R., Bracken M. B. Maternal smoking and congenital malformations: an epidemiological study. J Epidemiol Community Health. 1978 Jun;32(2):102–107. doi: 10.1136/jech.32.2.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Khoury M. J., Erickson J. D., James L. M. Etiologic heterogeneity of neural tube defects. II. Clues from family studies. Am J Hum Genet. 1982 Nov;34(6):980–987. [PMC free article] [PubMed] [Google Scholar]
  16. Khoury M. J., Erickson J. D., James L. M. Etiologic heterogeneity of neural tube defects: clues from epidemiology. Am J Epidemiol. 1982 Apr;115(4):538–548. doi: 10.1093/oxfordjournals.aje.a113335. [DOI] [PubMed] [Google Scholar]
  17. Khoury M. J., Weinstein A., Panny S. R., Holtzman N. A., Lindsay P. K., Warthen F. J., Street N. A., Robertson M. O., Farrell K. P., Eisenberg M. Epidemiology of sentinel birth defects in Maryland, 1984. Md Med J. 1986 Oct;35(10):837–845. [PubMed] [Google Scholar]
  18. Landesman-Dwyer S., Emanuel I. Smoking during pregnancy. Teratology. 1979 Feb;19(1):119–125. doi: 10.1002/tera.1420190116. [DOI] [PubMed] [Google Scholar]
  19. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  20. Naeye R. L. Relationship of cigarette smoking to congenital anomalies and perinatal death. A prospective study. Am J Pathol. 1978 Feb;90(2):289–294. [PMC free article] [PubMed] [Google Scholar]
  21. Opitz J. M., Gilbert E. F. CNS anomalies and the midline as a "developmental field". Am J Med Genet. 1982 Aug;12(4):443–455. doi: 10.1002/ajmg.1320120408. [DOI] [PubMed] [Google Scholar]
  22. Saxén I. Cleft lip and palate in Finland: parental histories, course of pregnancy and selected environmental factors. Int J Epidemiol. 1974 Sep;3(3):263–270. doi: 10.1093/ije/3.3.263. [DOI] [PubMed] [Google Scholar]
  23. Saxén I. Epidemiology of cleft lip and palate. An attempt to rule out chance correlations. Br J Prev Soc Med. 1975 Jun;29(2):103–110. [PMC free article] [PubMed] [Google Scholar]
  24. Shiono P. H., Klebanoff M. A., Berendes H. W. Congenital malformations and maternal smoking during pregnancy. Teratology. 1986 Aug;34(1):65–71. doi: 10.1002/tera.1420340109. [DOI] [PubMed] [Google Scholar]
  25. Spranger J., Benirschke K., Hall J. G., Lenz W., Lowry R. B., Opitz J. M., Pinsky L., Schwarzacher H. G., Smith D. W. Errors of morphogenesis: concepts and terms. Recommendations of an international working group. J Pediatr. 1982 Jan;100(1):160–165. doi: 10.1016/s0022-3476(82)80261-8. [DOI] [PubMed] [Google Scholar]
  26. UNDERWOOD P., HESTER L. L., LAFFITTE T., Jr, GREGG K. V. THE RELATIONSHIP OF SMOKING TO THE OUTCOME OF PREGNANCY. Am J Obstet Gynecol. 1965 Jan 15;91:270–276. doi: 10.1016/0002-9378(65)90211-5. [DOI] [PubMed] [Google Scholar]
  27. Yerushalmy J. The relationship of parents' cigarette smoking to outcome of pregnancy--implications as to the problem of inferring causation from observed associations. Am J Epidemiol. 1971 Jun;93(6):443–456. doi: 10.1093/oxfordjournals.aje.a121278. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

RESOURCES