Published June 10, 2013 // JCB vol. 201 no. 6 903-913
The Rockefeller University Press, doi: 10.1083/jcb.201301091

The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo

Video 1 AC-invadopodia turn over dynamically before basement membrane breaching.

Video 2 An AC-invadopodium presages and then occupies the site of basement membrane breach.

Video 3 Invasive protrusion growth during basement membrane transmigration.

Video 4 The invadopodia-to-invasive protrusion transition.

Video 5 UNC-40::GFP enriches at the basement membrane breach.

Video 6 UNC-40 accelerates basement membrane gap opening.

Video 7 F-actin formation is focused at sites of UNC-40::GFP enrichment.

Video 8 F-actin formation is focused at the basement membrane breach in wild-type animals.

Video 9 F-actin formation is not focused at basement membrane breaches in unc-40 mutants.

Supplemental material (PDF)